Publikationen
Zeitschriftenartikel
31. Stoichiometries and stability of CRISPR-Cascade complexes with varying spacer length revealed by native mass spectrometryS Wittig, I Songailiene, C Schmidt (2020)J Am Soc Mass Spectrom. In press. doi:10.1021/jasms.9b00011. 30. Control of p21Cip by BRAP is Crisitcal for Cardiomyocyte Cell Cycle Progression and SurvivalC Volland, P Schott, M Didié, J Männer, B Unsöld, K Toischer, C Schmidt, H Urlaub, K Nickels, R Knöll, A Schmidt, K Guan, G Hasenfuß, T Seidler (2019)Cardiovasc Res. 116(3):592-604. doi: 10.1093/cvr/cvz17729. Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosomeSV Faull, AMC Lau, C Martens, Z Ahdash, H Yebenes, C Schmidt, F Beuron, NB Cronin, EP Morris #, A Politis # (2019)Nat commun 10:3814.28. Decision making in Cascade complexes harboring crRNAs of altered lengthI Songailiene, M Rutkauskas, T Sinkunas, E Manakova, S Wittig, C Schmidt, V Siksnys #, R Seidel # (2019)Cell Rep 28(12):3157-3166.27. Protein-Lipid Interactions Stabilize the Oligomeric State of BOR1p from Saccharomyces cerevisiae.E pyle, C Guo, T Hofmann, C Schmidt, O Ribiero, A Politis, B Byrne (2019)Anal Chem 91(20):13071-13079. doi: 10.1021/acs.analchem.9b03271.26. The CroCo cross-link converter: a user-centred tool to convert results from crosslinking mass spectrometry experiments.J Bender, C Schmidt (2019)Bioinformatics. 36(4):1296-1297. doi: 10.1093/bioinformatics/btz732.25. Instrument response of phosphatidylglycerol lipids with varying fatty acyl chain length in nano-ESI shotgun experimentsT Hofmann, C Schmidt (2019)Chemistry and Physics of Lipids. 223:104782 24. Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice GuidelinesC Iacobucci*, C Piotrowski*, R Aebersold, BC Amaral, P Andrews, C Borchers, NI Brodie, JE Bruce, S Chaignepain, JD Chavez, S Claverol, J Cox, G Degliesposti, M-Q Dong, N Edinger, C Emanuelsson, M Gay. M Götze, FC Gozzo, C Gutierrez, C Haupt, AJR Heck, F Herzog, L Huang, MR Hoopmann, N Kalisman, O Klykov, Z Kukacka, F Liu, MJ MacCoss, K Mechtler, R Mesika, RL Moritz, N Nagaraj, V Nesati, R Ninnis, P Novák, FJ O’Reilly, M Pelzing, E Petrotchenko, L Piersimoni, M Plasencia, T Pukala, KD Rand, J Rappsilber, D Reichmann, C Sailer, CP Sarnowski, RA Scheltema, C Schmidt , D Schriemer, DC Schriemer, Y Shi, JM Skehel, M Slavin, F Sobott, V Solis-Mezarino, H Stephanowitz, F Stengel, CE Stieger, M Trnka, M Vilaseca, R Viner, Y Xiang, S Yilmaz, A Zelter, D Ziemanowicz, A Leitner #, A Sinz # (2019)Analytical Chemistry. 91(11):6953-6961 doi: 10.1021/acs.analchem.9b00658.23. Structural and functional analysis of the human pyruvate dehydrogenase complex suggest a “division-of-labor” mechanism by local E1 and E3 clustersS Prajapati *, D Haselbach *, S Wittig, MS Patel, A Chari, C Schmidt *# , H Stark #, K Tittmann # (2019)Structure. 27(7):1124-1136 doi: 10.1016/j.str.2019.04.009. 22. Oligomerisation of Synaptobrevin-2 Studied by Native Mass Spectrometry and Chemical Cross-LinkingS Wittig, C Haupt, W Hoffmann, S Kostmann, K Pagel, C Schmidt (2019)Journal of The American Society for Mass Spectrometry 30(1):149-160. 21. A novel sample preparation strategy for shotgun lipidomics of phospholipids employing multilamellar vesiclesM Frick, T Hofmann, C Haupt, C Schmidt (2018)Analytical and Bioanalytical Chemistry 410(18):4253-4258. 20. Combining chemical cross-linking and mass spectrometry of intact protein complexes to study the architecture of multi-subunit protein assemblies C Haupt *, T Hofmann *, S Wittig *, S Kostmann, A Politis, C Schmidt (2017) Journal of Visualised Experiments 129:56747. 19. Structure of the human MHC-I peptide-loading complex A Blees, D Januliene, T Hofmann, N Koller, C Schmidt, S Trowitzsch #, A Möller #, R Tampé # (2017)Nature 551(7681):525-528. 18. Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding A Scacioc, C Schmidt #, T Hofmann, H Urlaub, K Kühnel #, Á Pérez-Lara # (2017)Scientific Reports 7:14008. 17. Accommodating protein dynamics in the modelling of chemical cross-links M Degiacomi #, C Schmidt, AJ Baldwin, JLP Benesch # (2017)Structure 25(11):1751-1757. 16. Small molecule-induced soluble oligomers of a-synuclein with helical structure L Fonseca-Ornelas, C Schmidt, AR Camacho-Zarco, CO Fernandez, S Becker, M Zweckstetter (2017)Chemistry 23(53):13010-13014. 15. Acetylation and phosphorylation control both local and global stability of the chloroplast F1 ATP synthase C Schmidt #, V Beilsten-Edmands, S Mohammed, CV Robinson # (2017)Scientific Reports 7:44068. 14. Surface Accessibility and Dynamics of Macromolecular Assemblies Probed by Covalent Labeling Mass Spectrometry and Integrative Modeling C Schmidt, JA Macpherson, AM Lau, KW Tan, F Fraternali, A Politis (2017)Analytical Chemistry 89(3):1459-1468. 13. Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase MT Mazhab-Jafari, A Rohou, C Schmidt, SA Bueler, S Benlekbir, CV Robinson, JL Rubinstein (2017)Nature 539(7627):118-122. 12. Dimer interface of bovine cytochrome c oxidase is influenced by local posttranslational modifications and lipid binding I Liko, MT Degiacomi, S Mohammed, S Yoshikawa, C Schmidt #, CV Robinson # (2016) PNAS 113(29):8230-8235. 11. Uncovering the Early Assembly Mechanism for Amyloidogenic ß2-Microglobulin Using Cross-linking and Native Mass Spectrometry Z Hall, C Schmidt, A Politis (2016) The Journal of Biological Chemistry 291(9):4626-4637. 10. eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics V Beilsten-Edmands, Y Gordiyenko, JCK Kung, S Mohammed, C Schmidt #, CV Robinson # (2015)Cell Discovery 1:15020. 9. Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90 N Morgner *, C Schmidt *, V Beilsten-Edmands *, IO Ebong, NA Patel, E Kirschke, S Daturpalli, SE Jackson, D Agard, CV Robinson (2015) Cell Reports 11(5):759-769. 8. Topological models of heteromeric protein assemblies from mass spectrometry: Application to the yeast eIF3:eIF5 complex A Politis *, C Schmidt *, E Tjioe, AMSandercock, K. Lasker, Y Gordiyenko, D Russel, A Sali #, CV Robinson # (2015) Chemistry & Biology 22(1):117-128. 7. A comparative cross-linking strategy to probe conformational changes in protein complexes C Schmidt, CV Robinson (2014) Nature protocols 9(9):2224-2236. 6. Interactions of dimeric eIF2B with eIF2 facilitate nucleotide exchange Y Gordiyenko *, C Schmidt *, MD Jennings, D Matak-Vinkovic, GD Pavitt #, CV Robinson # (2014)Nature Communications 5:3902. 5. Relative quantification of pre-catalytic and catalytically active spliceosomes: a comparative study of metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count C Schmidt *, M Gronborg *, J Deckert, S Bessonov, T Conrad, R Lührmann, H Urlaub (2014)RNA 20(3):406-420. 4. Crystal Structure of the Human Short Coiled Coil Protein and Insights into SCOC-FEZ1 Complex Formation C Behrens, B Binotti, C Schmidt, CV Robinson, JJ Chua, K Kühnel (2013)PLoS One 8(10):e76355. 3. Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation C Schmidt, M Zhou, H Marriott, N Morgner, A Politis, CV Robinson (2013)Nature Communications 4:1985. 2. An automated in-gel digestion/iTRAQ-labeling workflow for robust quantification of gel-separated proteins C Schmidt, D Hesse, M Raabe, H Urlaub, O Jahn (2013)Proteomics 13(9):1417-1422. 1. Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring C Schmidt, C Lenz, M Grote, R Lührmann, H Urlaub (2010)Analytical Chemistry 82:2784-2796.
Review-Artikel und Buchkapitel
14. Mass spectrometry of membrane protein complexesJ Bender, C Schmidt (2019)Biological Chemistry. In Press13. Mass Spectrometry – a Versatile Tool for Characterising the Lipid Environment of Membrane Protein AssembliesM Frick, C Schmidt (2019)Chemistry and Physics of Lipids 221:145-157.12. Biophysical methods: behind the scenes of the cryo-EM revolution C Schmidt #, CV Robinson # (2017) Current Opinion in Structural Biology 46:ix-xi.11. Combining Cross-linking Mass Spectrometry (CX-MS) and Cryo-electron Microscopy (cryo-EM) for Structural Elucidations of Large Protein Complexes C Schmidt, H Urlaub (2017)Current Opinion in Structural Biology 46:157-168.10. Structural characterisation of medically relevant protein assemblies by integrating mass spectrometry with computational modelling A Politis #, C Schmidt # (2017)Journal of Proteomics 175:34-41. 9. Mass spectrometry of macromolecular protein assemblies. Insights into eukaryotic translation initiation C Schmidt, V Beilsten-Edmands, CV Robinson (2016) Journal of Molecular Biology 428(2 Pt A):344-356. 8. Mass spectrometry to study heterogeneous chaperone complexes C Schmidt, V Beilsten-Edmands, CV Robinson (2015)Oncotarget 6(21):18276-18281. 7. Analyzing the protein assembly and dynamics of the human spliceosome with SILAC C Schmidt, M Raabe, R Lührmann, H Urlaub (2014) Methods in Molecular Biology 1188:227-244.6. Dynamic protein ligand interactions – insights from mass spectrometry C Schmidt, CV Robinson (2014)FEBS Journal 281(8):1950-1964.5. Absolute quantification of proteins using standard peptides and multiple reaction monitoring C Schmidt, H Urlaub (2012)Methods in Molecular Biology 893:249-265.4. Quantitative mass spectrometry-based proteomics: an overview M Nikolov, C Schmidt, H Urlaub (2012)Methods in Molecular Biology 893:85-100.3. Investigation of protein-RNA interactions by mass spectrometry--Techniques and applications C Schmidt, K Kramer, H Urlaub (2012)Journal of Proteomics 75(12):3478-3494.2. Analysis of protein complexes by (quantitative) mass spectrometry C Schmidt, H Urlaub (2011). “RNA splicing. The complete guide for Biomedical Scientists”. (eds Stamm, S., Smith, J., Lührmann, R.) WILEY-VCH, 366-379.1. iTRAQ-labeling of in-gel digested proteins for relative quantification C Schmidt, H Urlaub (2009)Methods in Molecular Biology 564:207-226.
Andere Publikationen
4. Identifizierung von Lipiden aus LiposomenM Frick, C SchmidtBioSpektrum 25(2):167-169. 3. Proteomic basics - Quantification and posttranslational modifications of proteins: The 3rd European summer school in Kloster Neustift K Marcus, C Schmidt, H Urlaub (2009)Journal of Proteomics [EPub].2. Proteomic basics--sample preparation and separation': the 1st European Summer School in Kloster Neustift, 12-18 August, 2007 Brixen/Bressanone, South Tyrol, Italy K Marcus, E Kühn-Hölsken, C Schmidt, T Schulenborg, H Urlaub (2008)Proteomics 8:230-233.1. Protein-Quantifizierung nach In-Gel Verdau und iTRAQ-Markierung C Schmidt, H Urlaub, C Lenz (2008)Laborwelt 9(4):12-14.
*contributed equally, #co-corresponding authors