Martin-Luther-Universität Halle-Wittenberg

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Patente

Rudolph, R., Opitz, U., Kohnert, U. & Fischer, S. (1990) A Preparation of Plasminogen Activator Expressed in Prokaryonts Internat. Patent Application WO 90/03388

Rudolph, R. & Fischer, S. (1990) Process for Obtaining Renatured Proteins United States Patent 4,933,434

Rudolph, R., Buchner, J. & Lenz, H. (1991) Process for Activation of Recombinant Protein Produced by Prokaryotes United States Patent 5,077,392

Rudolph, R., Kopetzki, E., Fischer, S. Grossman, A. & Höll-Neugebauer, B. (1991) Process for Enzymatically Treating Substrates Internat. Patent Application WO91/10910

Rudolph, R., Höll-Neugebauer, B. & Buchner, J. (1993) Method of Stabilizing Proteins During Optical Tests Internat. Patent Application WO93/02211

Stern, A., Kohnert, U., Rudolph, R., Fischer, S. & Martin, U. (1993) Thrombolytically Active Non-Glycosylated Protein United States Patent 5,223,256

Buchner, J., Madeker, J. & Rudolph, R. (1993) Verfahren zur Stabilisierung von Proteinen European Patent Application 0 556 726 A1

Rudolph, R., Buchner, J. & Lenz, H. (1994) Aktivierung von gentechnologisch hergestellten, in Prokaryonte exprimierten Antikörpern European Patent Application 0 64 926 B1

Kohnert, U. & Rudolph, R. (1994) Stabilized Compositions Containing Non-Glysylated Human Tissue Type Plasminogen Activator Derivative K2P pro United States Patent 5,352,452

Kohnert, U. & Rudolph, R. (1994) Compositions Containing Non-Glycosylated Human Tissue Type Plasminogen Activator United States Patent 5,352,453

Kohnert, U. & Rudolph, R. (1994) Stabilized Compositions Having Human Tissue Type Plasminogen Activator Enzymatic Activity United States Patent 5,366,730

Kohnert, U., & Rudolph, R. (1995) Compositions Containing Glyosylated Molecules Having Human Tissue Type Plasminogen Activator Enzymatic Activity United States Patent 5,409,699

Michaelis, U., Rudolph, R., Jarsch, M., Kopetzki, E., Burtscher, H. & Schumacher, G. (1995) Process for the Production and Renaturation of Recombinant, Biologically Active, Eukaryotic Alkine Phosphatase United States Patent 5,434,067

Kohnert, U. & Rudolph, R. (1995) Stabilisierung von K1K2P Pro European Patent 0458949 B1

Rudolph, R., Fischer, S. & Mattes, R. (1995) Process for the Activitation of T-PA or ING after Genetic Expression in Prokaryotes United States Patent 5,453,363

Jacob, U., Buchner, J., Wiech, H., Zimmermann, R. & Rudolph, R. (1995) Method for the Stabilization of Proteins using Heat Shock Protein Hsp90 United States Patent 5,474,892

Kopetzki, E., Rudolph, R. & Grossmann, A. (1996) Recombinant Core-Streptavidin United States Patent 5,489,528

Ambrosius, D., Dony, C. & Rudolph, R. (1996) Activation of Recombinant Proteins United States Patent 5,578,710

Lang, K., Bartke, I., Naujoks, K., Rudolph, R. & Stern, A. (1997) Process for the Preparation of Biologically Active NGF by Genetic Engineering European Patent Application 0544293B1

Ambrosius, D. & Rudolph, R: Process for the Reactivation of Denatured Protein United States Patent 5,618,927

Kopetzki, E., Rudolph, R. & Grossmann, A. (1997) Recombinant Core Streptavidin United States Patent 5,672,691

Michaelis, U., Rudolph, R. & Winter, G. (1999) Stable Lyophilized Pharmaceutical Preparation of G-CSF United States Patent 5, 919, 443

Michaelis, U., Rudolph, R. & Winter, G. (1999) Aqueous Pharmaceutical Preparations of G-CSF with a Long Shelf Life United States Patent 5, 919, 757

Ambrosius, D., Dony, C. & Rudolph, R. (1999) Methods for Making Neisseria or Hemophilus IgA Protease and DNA Encoding the Proteases United States Patent 5,965,424

Wohlrab, J. & Rudolph, R. (1999) Arginin zur topischen Applikation für die Therapie und Prophylaxe krankhafter Veränderungen der Haut und/oder zur kosmetischen Anwendung Deutsche Patentanmeldung 19946675.0

Rattenholl, A., Grossmann, A., Schwarz, E. & Rudolph, R. (2000) Verfahren zur Gewinnung von aktivem ß-NGF European Patent Application 0994188A1

Ambrosius, D., Rudolph, R.; Schäffner, J. & Schwarz, E. (2001) Process for the Production of Naturally Folded and Secreted Proteins United States Patent 6,309,861

Glockshuber, R.; Wunderlich, M.; Skerra, A. & Rudolph, R. (2001) Yield when Disulfide-Bonded Proteins are Secreted United States Patent 6,333,.175

Lilie, H.; Richter, S.; Rudolph, R. & Stubenrauch, K.-G. (2002) Method for Producing Chimeric Polypeptides United States Patent 6,437,095

Ambrosius, D.; Rudolph, R.; Schäffner, J. & Schwarz, E. (2002) Process for the Production of Naturally Folded and Secreted Proteins by Co-Sekretion of Molecular Chaperones United States Patent 6,455,279

Fiedler, U. & Rudolph, R. ( 2002) Fabrication of Beta-Pleated Sheet Proteins with Specific Binding Properties European Patent Application 1200583 A

Rudolph, R.; Schwarz, E. Herr, G. & Hillger, F. (2002) Production of Recombinant BMP-2 International Patent Application WO 0244203 A

Müller, R., Thalhofer, J.-P, Rexer, B., Schmuck, R., Geipel, F., Glaser, S., Schön, H., Meier, T., Rudolph, R., Lilie, H. & Schott, B.(2002) Recombinant Proteinase K International Patent Application WO 02 072634 A2

Böhm, G., Rudolph, R., Schmidt, U. & Esser, D. (2002) Modular Transport Systems for Molecular Substances and Production and Use Thereof International Patent Application WO 0132851A3

Grauschopf, U., Kuntzsch, A., Oschmann, J. & Rudolph, R. (2003)
Verfahren zur Herstellung nativ gefalteter Membranproteine
Internat. Patent Application WO 03051908

Lilie, H., Raue, U. & Rudolph, R. (2003)
Verfahren zur Renaturierung von Proteinen
Deut. Patentanmeldung 10161577.9

Gleiter, S. Jahn, T., Lilie, H. & Rudolph, R. (2003)
Herstellung von virusanalogen Partikeln durch Assemblierung von Kapsomeren oder von Kapsomeren, an die biologisch aktive Makromoleküle gebunden sind, bei gleichzeitiger Verpackung der Makromoleküle, Deut.
Patentanmeldung 10237639. 5-41

Bordusa, F., Rudolph, R. & Wekofsky, N. (2004) Verfahren zur Synthese und selektiven biokatalytischen Modifizierung von Peptiden, Peptidmimetika und Proteinen Deutsche Patentanmeldung 102 40 098.9-42

Boehm, G., Rudolph, R., Schmidt, U. & Esser, D. (2005) Modular transport systems for molecular substances and production and use thereof, US Patent Application 2005/0266020 A1

Rudolph, R., Bordusa, F. & Wehofsky, N. (2006) Method for the synthesis and selective biocatalytic modification of peptides, peptide mimetics and proteins, US Patent Application 20060149035

Fiedler, U. & Rudolph, R. (2007) Design of beta-sheet proteins with specific binding properties, US Patent Application 20070111287

Rudolph, R., Söhling, B. & Ajamaluddin, M. (2007) Periplasmische Produktion therapeutisch relevanter Proteine durch Fusion an Escherichia coli Ecotin, Deut. Patentanmeldung 102005050732 A1

Mueller, R., Thalhofer, J.-P., Rexer, B., Schmuck, R., Geipel, F., Glaser, S., Schoen, H., Meier, T., Rudolph, R., Lilie, H. & Schott, B. (2007) Recombinant Proteinase K, US Patent Application US 2007/0099283 A1

Fiedler, M., Fiedler, U. & Rudolph, R. (2008) Generation of artificial binding proteins on the basis of ubiquitin proteins, US Patent Application 20080171851

Rudolph, R., Schwarz, E., Herr, G. & Hillger, F. (2008) Production of recombinant BMP-2, US Patent 7,354,901 B2

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