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Kalbas, D., Meleshin, M., Liebscher, S., Zessin, M.,  Melesina, J., Schiene-Fischer, C., Bülbül, E.F., Bordusa, F., Sippl, W.,  Schutkowski, M. (2022) Small Changes Make the Difference for SIRT2: Two  Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives.  Biochemistry. doi: 10.1021/acs.biochem.2c00211.

Schiene-Fischer, C., Fischer, G., Braun, M. (2022)    Non-Immunosuppressive Cyclophilin Inhibitors. Angew Chem Int Ed Engl.  Mar 15:e202201597.


Guo, Z., Hong, S.Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., Ullman, B.R., Tse, C.M., Tarmakova, Z., Schiene-Fischer, C., Fischer, G., Coe, I., Paavilainen, V.O., Sun, Z., Liu, J.O. (2019) Rapamycin-inspired macrocycles with new target specificity. Nat Chem. 3, 254-263.

Guo, Z., Cheng, Z., Wang, J., Liu, W., Peng, H., Wang, Y., Rao, A.V.S., Li, R.J., Ying, X., Korangath, P., Liberti, M.V., Li, Y., Xie, Y., Hong, S.Y., Schiene-Fischer, C., Fischer, G., Locasale, J.W., Sukumar, S., Zhu, H., Liu, J.O. (2019) Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays. Angew Chem Int Ed Engl. 58(48), 17158-17162.


Ünal, C.M., Berges, M., Smit, N., Schiene-Fischer, C., Priebe, C., Strowig, T., Jahn, D., Steinert, M. (2018) PrsA2 (CD630_35000) of Clostridioides difficile Is an Active Parvulin-Type PPIase and a Virulence Modulator. Front Microbiol. 9, 2913.

Schumann, M., Maleševiæ, M., Hinze, E., Mathea, S., Meleshin, M., Schutkowski, M., Haehnel, W., Schiene-Fischer, C. (2018) Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1. J Mol Biol. 307, 14-9.

Ernst, K., Eberhardt, N., Mittler, AK., Sonnabend, M., Anastasia, A., Freisinger, S., Schiene-Fischer, C., Maleševiæ, M., Barth, H. (2018) Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin. Toxins. 10(5). pii: E181

Schneider, S., Paulsen, H., Reiter, K.C., Hinze, E., Schiene-Fischer, C., Hübner, C.G. (2018)  Single molecule FRET investigation of pressure-driven unfolding of cold shock protein A. J Chem Phys. 148, 123336.


Ernst, K., Schmid, J., Beck, M., Hägele, M., Hohwieler, M., Hauff, P., Ückert, A.K., Anastasia, A., Fauler, M., Jank, T., Aktories, K., Popoff , M. R., Schiene-Fischer, C., Kleger, A., Müller, M., Frick, M., Barth, H. (2017) Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells. Sci Rep 7, 2724.

Schuster, M., Schnell, L., Feigl, P., Birkhofer, C., Mohr, K., Roeder, M., Carle, S., Langer, S., Tippel, F., Buchner, J., Fischer, G., Hausch, F., Frick, M., Schwan, C., Aktories, K., Schiene-Fischer, C., Barth, H. (2017) The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep 7, 613.


Ernst, K., Liebscher, M., Mathea, S., Granzhan, A., Schmid, J., Popoff, M. R., Ihmels, H., Barth, H., and Schiene-Fischer, C. (2016) A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin, Sci Rep 6, 20301.

Schumann, M., Ihling, C. H., Prell, E., Schierhorn, A., Sinz, A., Fischer, G., Schiene-Fischer, C., and Malesevic, M. (2016) Identification of low abundance cyclophilins in human plasma, Proteomics. 16, 2815-2826.

Schuster, S., Roessler, C., Meleshin, M., Zimmermann, P., Simic, Z., Kambach, C., Schiene-Fischer, C., Steegborn, C., Hottiger, M. O., and Schutkowski, M. (2016) A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions, Sci Rep 6, 22643.

Villmow, M., Baumann, M., Malesevic, M., Sachs, R., Hause, G., Fändrich, M., Balbach, J., and Schiene-Fischer, C. (2016) Inhibition of Abeta(1-40) fibril formation by cyclophilins, Biochem J 473, 1355-1368.

Chen, J., Liefke, R., Jiang, L., Wang, J., Huang, C., Gong, Z., Schiene-Fischer, C., and Yu, L. (2016) Biochemical Features of Recombinant Human Cyclophilin J, Anticancer Res 36, 1175-1180.


Schmidt, M., Rohou, A., Lasker, K., Yadav, J. K., Schiene-Fischer, C., Fändrich, M., and Grigorieff, N. (2015) Peptide dimer structure in an Abeta(1-42) fibril visualized with cryo-EM, Proc Natl Acad Sci U S A 112, 11858-11863.

Schiene-Fischer, C. (2015) Multidomain Peptidyl Prolyl cis/trans Isomerases, Biochim Biophys Acta 1850, 2005-2016.

Ernst, K., Langer, S., Kaiser, E., Osseforth, C., Michaelis, J., Popoff, M. R., Schwan, C., Aktories, K., Kahlert, V., Malesevic, M., Schiene-Fischer, C., and Barth, H. (2015) Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins, J Mol Biol 427, 1224-1238.

Schiene-Fischer, C., Peptidyl Prolyl cis/trans Isomerases. In: eLS. John Wiley & Sons, Ltd: Chichester. (2015)  DOI: 10.1002/9780470015902


Hoffmann, H., and Schiene-Fischer, C. (2014) Functional aspects of extracellular cyclophilins, Biol Chem 395, 721-735.


Malesevic, M., Gutknecht, D., Prell, E., Klein, C., Schumann, M., Nowak, R. A., Simon, J. C., Schiene-Fischer, C., and Saalbach, A. (2013) Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147, J Med Chem 56, 7302-7311.

Schiene-Fischer, C., Aumüller, T., and Fischer, G. (2013) Peptide bond cis/trans isomerases: a biocatalysis perspective of conformational dynamics in proteins, Top Curr Chem 328, 35-67.

Morgado, I., Wieligmann, K., Bereza, M., Ronicke, R., Meinhardt, K., Annamalai, K., Baumann, M., Wacker, J., Hortschansky, P., Malesevic, M., Parthier, C., Mawrin, C., Schiene-Fischer, C., Reymann, K. G., Stubbs, M. T., Balbach, J., Gorlach, M., Horn, U., and Fändrich, M. (2012) Molecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment, Proc Natl Acad Sci U S A 109, 12503-12508.


von Hahn, T., Schiene-Fischer, C., Van, N. D., Pfaender, S., Karavul, B., Steinmann, E., Potthoff, A., Strassburg, C., Hamdi, N., Abdelaziz, A. I., Sarrazin, C., Muller, T., Berg, T., Trepo, E., Wedemeyer, H., Manns, M. P., Pietschmann, T., and Ciesek, S. (2012) Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication, Gastroenterology 143, 439-447 e431.

Schiene-Fischer, C., AvrRpt2 Peptidase. In: Handbook of Proteolytic Enzymes, 3rd Edn. Elsevier Ltd. (2012) . ISBN: 978-0-12-382219-2


Theuerkorn, M., Fischer, G., and Schiene-Fischer, C. (2011) Prolyl cis/trans isomerase signalling pathways in cancer, Curr Opin Pharmacol 11, 281-287.

Lee, T. H., Chen, C. H., Suizu, F., Huang, P., Schiene-Fischer, C., Daum, S., Zhang, Y. J., Goate, A., Chen, R. H., Zhou, X. Z., and Lu, K. P. (2011) Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function, Mol Cell 42, 147-159.

Mathea, S., Li, S., Schierhorn, A., Jahreis, G., and Schiene-Fischer, C. (2011) Suppression of EGFR autophosphorylation by FKBP12, Biochemistry 50, 10844-10850.

Helbig, S., Patzer, S. I., Schiene-Fischer, C., Zeth, K., and Braun, V. (2011) Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone, J Biol Chem 286, 6280-6290.


Aumüller, T., Jahreis, G., Fischer, G., and Schiene-Fischer, C. (2010) Role of prolyl cis/trans isomers in cyclophilin-assisted Pseudomonas syringae AvrRpt2 protease activation, Biochemistry 49, 1042-1052.

Liebscher, M., Haupt, K., Yu, C., Jahreis, G., Lücke, C., and Schiene-Fischer, C. (2010) Rational design of novel peptidic DnaK ligands, Chembiochem 11, 1727-1737.

Yau, W. L., Blisnick, T., Taly, J. F., Helmer-Citterich, M., Schiene-Fischer, C., Leclercq, O., Li, J., Schmidt-Arras, D., Morales, M. A., Notredame, C., Romo, D., Bastin, P., and Späth, G. F. (2010) Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability, PLoS Negl Trop Dis 4, e729.


Peng, H., Vijayakumar, S., Schiene-Fischer, C., Li, H., Purkerson, J. M., Malesevic, M., Liebscher, J., Al-Awqati, Q., and Schwartz, G. J. (2009) Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation, J  Biol  Chem 284, 6465-6475.

Smajlovic, A., Berbic, S., Schiene-Fischer, C., Tusek-Znidaric, M., Taler, A., Jenko-Kokalj, S., Turk, D., and Zerovnik, E. (2009) Essential role of Pro 74 in stefin B amyloid-fibril formation: dual action of cyclophilin A on the process, FEBS Lett 583, 1114-1120.

Daum, S., Schumann, M., Mathea, S., Aumüller, T., Balsley, M. A., Constant, S. L., de Lacroix, B. F., Kruska, F., Braun, M., and Schiene-Fischer, C. (2009) Isoform-specific inhibition of cyclophilins, Biochemistry 48, 6268-6277.

Bauer, K., Kretzschmar, A. K., Cvijic, H., Blumert, C., Loffler, D., Brocke-Heidrich, K., Schiene-Fischer, C., Fischer, G., Sinz, A., Clevenger, C. V., and Horn, F. (2009) Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells, Oncogene 28, 2784-2795.

Baum, N., Schiene-Fischer, C., Frost, M., Schumann, M., Sabapathy, K., Ohlenschlager, O., Grosse, F., and Schlott, B. (2009) The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis, Oncogene 28, 3915-3925.


Payeli, S. K., Schiene-Fischer, C., Steffel, J., Camici, G. G., Rozenberg, I., Luscher, T. F., and Tanner, F. C. (2008) Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations, Atherosclerosis 197, 564-571.


Wildemann, D., Schiene-Fischer, C., Aumüller, T., Bachmann, A., Kiefhaber, T., Lücke, C., and Fischer, G. (2007) A nearly isosteric photosensitive amide-backbone substitution allows enzyme activity switching in ribonuclease s, J Am Chem Soc 129, 4910-4918.

Liebscher, M., Jahreis, G., Lücke, C., Grabley, S., Raina, S., and Schiene-Fischer, C. (2007) Fatty acyl benzamido antibacterials based on inhibition of DnaK-catalyzed protein folding, J Biol Chem 282, 4437-4446.

Daum, S., Lucke, C., Wildemann, D., and Schiene-Fischer, C. (2007) On the benefit of bivalency in peptide ligand/pin1 interactions, J Mol Biol 374, 147-161.

Hohlbein, J., Steinhart, M., Schiene-Fischer, C., Benda, A., Hof, M., and Hubner, C. G. (2007) Confined diffusion in ordered nanoporous alumina membranes, Small 3, 380-385.


Daum, S., Fanghänel, J., Wildemann, D., and Schiene-Fischer, C. (2006) Thermodynamics of phosphopeptide binding to the human peptidyl prolyl cis/trans isomerase Pin1, Biochemistry 45, 12125-12135.


Golbik, R., Yu, C., Weyher-Stingl, E., Huber, R., Moroder, L., Budisa, N., and Schiene-Fischer, C. (2005) Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates, Biochemistry 44, 16026-16034.

Yu, C., Malesevic, M., Jahreis, G., Schutkowski, M., Fischer, G., and Schiene-Fischer, C. (2005) The architecture of protein-ligand binding sites revealed through template-assisted intramolecular peptide-peptide interactions, Angew Chem Int Ed Engl 44, 1408-1412.


Zhao, J., Micheau, J. C., Vargas, C., and Schiene-Fischer, C. (2004) cis/trans photoisomerization of secondary thiopeptide bonds, Chemistry 10, 6093-6101.

Schiene-Fischer, C. and Lücke, C., Secondary Amide Peptide Bond cis/trans Isomerization in Polypeptide Backbone Restructuring: Implications for Catalysis Protein. In: Folding Handbook. Part II. Edited by J. Buchner and T. Kiefhaber WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim (2004) ISBN: 3-527-30784-2


Zhao, J., Wildemann, D., Jakob, M., Vargas, C., and Schiene-Fischer, C. (2003) Direct photomodulation of peptide backbone conformations, Chem Commun (Camb), 2810-2811.


Schiene-Fischer, C., Habazettl, J., Tradler, T., and Fischer, G. (2002) Evaluation of similarities in the cis/trans isomerase function of trigger factor and DnaK, Biol Chem 383, 1865-1873.

Schiene-Fischer, C., Habazettl, J., Schmid, F. X., and Fischer, G. (2002) The hsp70 chaperone DnaK is a secondary amide peptide bond cis-trans isomerase, Nat Struct Biol 9, 419-424.


Schiene-Fischer, C., and Fischer, G. (2001) Direct measurement indicates a slow cis/trans isomerization at the secondary amide peptide bond of glycylglycine, J Am Chem Soc 123, 6227-6231.

Schiene-Fischer, C., and Yu, C. (2001) Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases, FEBS Lett 495, 1-6.

2000 and before

Schiene, C., and Fischer, G. (2000) Enzymes that catalyse the restructuring of proteins, Curr Opin Struct Biol 10, 40-45.

Lopez-Ilasaca, M., Schiene, C., Kullertz, G., Tradler, T., Fischer, G., and Wetzker, R. (1998) Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor, J Biol Chem 273, 9430-9434.

Schiene, C., Reimer, U., Schutkowski, M., and Fischer, G. (1998) Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases, FEBS Lett 432, 202-206.