Veröffentlichungen
2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2000 1999 1998 1997 1996 1995 1994 19912023
Motlová, L., Šnajdr, I., Kutil, Z., Andris, E., Ptáček, J., Novotná, A., Nováková, Z., Havlínová, B., Tueckmantel, W., Dráberová, H., Majer, P., Schutkowski, M., Kozikowski, A., Rulíšek, L., Bařinka, C. (2023) Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6). ACS Chem Biol. doi: 10.1021/acschembio.3c00212.
Zessin, M., Meleshin, M., Hilscher, S., Schiene-Fischer, C., Barinka, C., Jung, M., Schutkowski, M.. (2023) Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines. Int J Mol Sci. 24(8):7416. doi: 10.3390/ijms24087416.
Meleshin, M., Koch, L., Wiedemann, C., Schutkowski, M. (2023) Synthesis of Complex Thiazoline-Containing Peptides by Cyclodesulfhydration of N-Thioacyl-2-Mercaptoethylamine Derivatives. Angew Chem Int Ed Engl. 62(25):e202301543. doi: 10.1002/anie.202301543.
Zessin, M., Meleshin, M., Sippl, W., Schutkowski, M. (2023) Continuous Histone Deacylase Activity Assays. Methods Mol Biol. 2589:411-428. doi: 10.1007/978-1-0716-2788-4_27.
Abdelsalam, M., Ibrahim, H.S., Krauss, L., Zessin, M., Vecchio, A., Hastreiter, S., Schutkowski, M., Schneider, G., Sippl, W. (2023) Development of Pyrazine-Anilinobenzamides as Histone Deacetylase HDAC1-3 Selective Inhibitors and Biological Testing Against Pancreas Cancer Cell Lines. Methods Mol Biol. 2589:145-155. doi: 10.1007/978-1-0716-2788-4_10. PMID: 36255623
2022
Sun, P., Wang, J., Khan, K.S., Yang, W., Ng, B.W., Ilment, N., Zessin, M., Bülbül, E.F., Robaa, D., Erdmann, F., Schmidt, M., Romier, C., Schutkowski, M., Cheng, A.S., Sippl, W. (2022) Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties. J Med Chem. 65(24):16313-16337. doi: 10.1021/acs.jmedchem.2c01132.
Weiss, S., Adolph, R.S., Schweimer, K., DiFonzo, A., Meleshin, M., Schutkowski, M., Steegborn, C. (2022) Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein. Int J Mol Sci. 23(21):12764. doi: 10.3390/ijms232112764.
Kalbas, D., Meleshin, M., Liebscher, S., Zessin, M., Melesina, J., Schiene-Fischer, C., Bülbül, E.F., Bordusa, F., Sippl, W., Schutkowski, M. (2022) Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives. Biochemistry. doi: 10.1021/acs.biochem.2c00211.
Zessin, M., Meleshin, M., Praetorius, L., Sippl, W., Barinka, C., Schutkowski, M. (2022) Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms. ACS Chem Biol. 17(6):1364-1375. doi: 10.1021/acschembio.1c00863.
Cheshmazar, N., Hemmati, S., Hamzeh-Mivehroud, M., Sokouti, B., Zessin, M., Schutkowski, M., Sippl, W., Nozad Charoudeh, H., Dastmalchi, S. (2022) Development of New Inhibitors of HDAC1-3 Enzymes Aided by In Silico Design Strategies. J Chem Inf Model. 62(10):2387-2397. doi: 10.1021/acs.jcim.1c01557.
Bülbül, E.F., Melesina, J., Ibrahim, H.S., Abdelsalam, M., Vecchio, A., Robaa, D., Zessin, M., Schutkowski, M., Sippl, W. (2022) Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors. Molecules. 27(8):2526. doi: 10.3390/molecules27082526.
Kutil, Z., Meleshin, M., Baranova, P., Havlinova, B., Schutkowski, M., Barinka, C. (2022) Characterization of the class IIa histone deacetylases substrate specificity. FASEB J. 36(5):e22287. doi: 10.1096/fj.202101663R.
Ruhs, S., Griesler, B., Huebschmann, R., Stroedecke, K., Straetz, N., Ihling, C., Sinz, A., Masch, A., Schutkowski, M., Gekle, M., Grossmann, C. (2022) Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1. FASEB J. 36(1):e22059. doi: 10.1096/fj.202100977RR.
2021
Ibrahim, H.S., Abdelsalam, M., Zeyn, Y., Zessin, M., Mustafa, A.M., Fischer, M.A., Zeyen, P., Sun, P., Bülbül, E.F., Vecchio, A., Erdmann, F., Schmidt, M., Robaa, D., Barinka, C., Romier, C., Schutkowski, M., Krämer, O.H., Sippl, W. (2021) Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity. Int J Mol Sci. 23(1):369. doi: 10.3390/ijms23010369.
Zessin, M., Meleshin, M., Simic, Z., Kalbas, D., Arbach, M., Gebhardt, P., Melesina, J., Liebscher, S., Bordusa, F., Sippl, W., Barinka, C., Schutkowski, M. (2021) Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher. Bioorg Chem. 117:105425. doi: 10.1016/j.bioorg.2021.105425.
2020
Schnatbaum, K., Solis-Mezarino, V., Pokrovsky, D., Schäfer, F., Nagl, D., Hornberger, L., Zerweck, J., Knaute, T., Avramova-Nehmer, J., Schutkowski, M., Hornung, V., Wenschuh, H., Völker-Albert, M.C., Imhof, A., Reimer, U. (2020) New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag. Proteomics. 20(10):e2000007. doi: 10.1002/pmic.202000007.
Ustinova, K., Novakova, Z., Saito, M., Meleshin, M.,, Mikesova, J., Kutil, Z., Baranova, P., Havlinova, B. Schutkowski, M., Matthias, P., Barinka, C., (2020) The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation. J Biol Chem. , Jan 17. pii: jbc.RA119.011243. doi: 10.1074/jbc.RA119.0112
2019
Kutil, Z., Mikešová, J., Zessin, M., Meleshin, M., , Nováková, Z., Alquicer, G., Kozikowski, A., Sippl, W., Bařinka, C., Schutkowski, M., (2019) Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors. ACS Omega.4(22), 19895-19904. doi: 10.1021/acsomega.9b02808.
Zessin, M., Kutil, Z., Meleshin, M., , Nováková, Z., Ghazy, E., Kalbas, D., Marek, M., Romier, C., Sippl, W., Bařinka, C., Schutkowski, M. (2019) One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry.58(48), 4777-4789. doi: 10.1021/acs.biochem.9b00786.
Kutil, Z., Skultetyova, L., Rauh, D., Meleshin, M., Snajdr, I., Novakova, Z., Mikesova, J., Pavlicek, J., Hadzima, M., Baranova, P., Havlinova, B., Majer, P., Schutkowski, M., Barinka, C., (2019) The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries. FASEB J. 33(3), 4035-4045. doi: 10.1096/fj.201801680R.
2018
Schumann, M., Malešević, M., Hinze, E., Mathea, S., Meleshin, M.,, Schutkowski, M., Haehnel, W., Schiene-Fischer, C.(2018) Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1. J Mol Biol. 307, 14-19. doi: 10.1016/j.jmb.2018.10.002.
Maksimov, P., Basso, W., Zerweck, J., Schutkowski, M. , Reimer, U., Maksimov, A., Conraths, F.J., Schares, G. (2018) Analysis of Toxoplasma gondii clonal type-specific antibody reactions in experimentally infected turkeys and chickens. Int J Parasitol. pii: S0020-7519(18), 30134-6. doi: 10.1016/j.ijpara.2018.04.004.
Kalbas, D., Liebscher, S., Nowak, T., Meleshin, M., Pannek, M., Popp, C., Alhalabi, Z., Bordusa, F., Sippl, W., Steegborn, C., Schutkowski, M. (2018) Potent and Selective Inhibitors of Human Sirtuin 5. J Med Chem. 61, 2460-2471. doi: 10.1021/acs.jmedchem.7b01648.
Kutil, Z., Novakova, Z.,Meleshin, M., Mikesova, J., Schutkowski, M., Barinka, C (2018) Histone Deacetylase 11 Is a Fatty-Acid Deacylase. ACS Chem Biol. 13, 685-693. doi: 10.1021/acschembio.7b00942.
2017
Blüher, D., Laha, D., Thieme, S., Hofer, A., Eschen-Lippold, L., Masch, A., Balcke, G., Pavlovic, I., Nagel, O., Schonsky, A., Hinkelmann, R., Wörner, J., Parvin, N., Greiner, R., Weber, S., Tissier, A., Schutkowski, M., Lee, J., Jessen, H., Schaaf, G. & Bonas, U. (2017) A 1-phytase type III effector interferes with plant hormone signaling. Nat Commun. 8,2159. doi: 10.1038/s41467-017-02195-8.
Pannek, M., Simic, Z., Fuszard, M., Meleshin, M., Rotili, D., Mai, A., Schutkowski, M. & Steegborn, C. (2017) Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun. 8, 1513. doi:10.1038/s41467-017-01701-2.
Ruhs, S., Strätz, N., Quarch, K., Masch, A., Schutkowski, M., Gekle, M. & Grossmann, C. (2017) Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2. Sci Rep. 7 15340. doi:10.1038/s41598-017-15418-1.
Schmohl, L., Bierlmeier, J., von Kügelgen, N., Kurz, L., Reis, P., Barthels, F., Mach, P., Schutkowski, M., Freund, C. & Schwarzer, D. (2017) Identification of sortase substrates by specificity profiling. Bioorg Med Chem. 25, 5002-5007. doi: 10.1016/j.bmc.2017.06.033.
Palma, A., Tinti, M., Paoluzi, S., Santonico, E., Brandt, B. W., Hooft van Huijsduijnen, R., Masch, A., Heringa, J., Schutkowski, M., Castagnoli, L. & Cesareni, G. (2017) Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases. J Biol Chem. 292, 4942-4952. doi: 10.1074/jbc.M116.757518.
You, W., Rotili, D., Li, T. M. , Kambach, C., Meleshin, M., Schutkowski, M., Chua, K. F., Mai, A. & Steegborn, C. (2017) Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew Chem Int Ed Engl.56, 1007-1011. doi: 10.1002/anie.201610082.
2016
Schuster, S., Roessler, C.,Meleshin, M., Zimmermann, P., Simic, Z., Kambach, C., Schiene-Fischer, C., Steegborn, C., Hottiger ,M. O. & Schutkowski, M. (2016) A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Sci Rep 4, 22643.doi: 10.1038/srep22643.
2015
Rohe, A., Platzer, C., Masch, A.,Greiner, S., Henze, C., Ihling, C., Erdmann, F., Schutkowski, M.,Sippl, W. & Schmidt, M. (2015) Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.
Roessler, C., Tüting, C., Meleshin, M. , Steegborn, C., & Schutkowski, M. (2015) A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases. J Med Chem., 58, 7217-23. doi: 10.1021/acs.jmedchem.5b00293.
McCuaig, R.D., Dunn, J., Li. J., Masch, A., Knaute, T., Schutkowski, M., Zerweck, J. & Rao, S. (2015) PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation. Front Immunol., 6, 562. doi: 10.3389/fimmu.2015.00562.
Simic, Z., Weiwad, M., Schierhorn, A., Steegborn, C. & Schutkowski, M. (2015) The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters. Chembiochem., 16, 2337-47. doi: 10.1002/cbic.201500364.
Rumpf, T., Schiedel, M., Karaman, B. Roessler, C., North, B., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., & Jung, M. (2015) Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nature Struct. Biol., 6, 6263. doi: 10.1038/ncomms7263.
Polletta, L., Vernucci, E., Carnevale, I., Rotili, D., Nowak, T., Schutkowski, M., Pellegrini, L., Villanova, L., Sansone, L., Runci, A., Pucci, B., Fini, M., Mai, A., Russo, M.A., & Tafani, M. (2015) SIRT5 regulation of ammonia-induced autophagy/mitophagy. Feb 20:0. [Epub ahead of print]
2014
Maksimov, P., Zerweck, J., Dubey, J.P., Pantchev, N., Frey, C.F., Maksimov, A., Reimer, U., Schutkowski, M., Hosseininejad, M., Ziller, M., Conraths, F.J., Schares, G. (2013) Serotyping of Toxoplasma gondii in cats (Felis silvestris catus) reveals predominance of type II infections in Germany. PLOSone, 8(11), e80213
Schutkowski, M., Roessler, C., Fischer, F., & Steegborn, C. (2014) New assays and approaches for discovery and design of Sirtuin modulators. Expert Opinion On Drug Discovery, 9, 183-199
Perez-Bercoff, L., Valentini, D., Gaseitsiwe, S., Mahdavifar, S., Schutkowski, M., Poiret, T., Perez-Bercoff, A., Ljungman, P., & Maeurer, M.J. (2014) Whole CMV Proteome Pattern Recognition Analysis after HSCT Identifies Unique Epitope Targets Associated with the CMV Status. PLOSone, 9,, e89648
Roessler, C., Nowak, T., Pannek, M., Gertz, M., Nguyen, G.T.T., Scharfe, M., Born, I., Sippl, W., Steegborn, C., Schutkowski, M. (2014) Chemical probing of the human Sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors Angewandte Chemie DOI: 10.1002/anie.201402679
Schönberg, A, Bergner, E., Helm, S., Agne, B., Dünschede, B., Schünemann, D., Schutkowski, M., Baginsky, S. (2014) ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana. PLOSone, 9(10), e108344. doi: 10.1371/journal.pone.0108344. eCollection 2014
2013
Gertz, M., Fischer, F.,Nguyen, G.T.T., Lakshminarasimhan, M., Szczepankiewicz, B., Weyand, M., Schutkowski, M., & Steegborn, C. (2013) The Sirtuin inhibitor Ex-527 exploits their unique NAD+-dependent deacetylation mechanism. PNAS, 110(30), E2772-81
Rauh, D., Fischer, F., Gertz, M., Lakshminarasimhan, M., Bergbrede, T., Aladini, F., Becker, C.F.W., Zerweck, J., Schutkowski, M., & Steegborn, C. (2013) An acetylome peptide microarray reveals specificities and deacetylation substrates of all human Sirtuin isoforms. Nature Communications, 4, 2327
Tinti, M., Kiemer, L., Costa, S., Miller, M., Sacco, F., Olsen, J. V., Carducci, M., Paoluzi; S., Langone, F., Workman, C. T., Blom, N., Machida, K., Thomson, C. M., Schutkowski, M., Brunak, S., Mann, M., Mayer, B. J., Castagnoli, L., & Cesareni, G. (2013) The SH2 domain interaction landscape. Cell Reports, 3, 1-13
Lakshminarasimhan, M., Rauh, D. , Schutkowski, M., & Steegborn, C. (2013) Sirt1 activation by resveratrol is substrate sequence-selective. Aging, 5 (3), 1-4
Wolf, A., Rietscher, K., Glaß, M., Hüttelmaier, S., Schutkowski, M., Ihling, C., Sinz, A., Wingenfeld, A., Mun, A., & Hatzfeld, M. (2013) Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J. Cell Science, Advance Online Article, February 26, doi: 10.1242/ jcs.118992
Funkner, A., Parthier, C., Schutkowski, M., Zerweck, J., Lilie, H., Gyrych, N., Fischer, G., Stubbs, M.T., Ferrari, D.M. (2013) Peptide binding by catalytic domains of the protein disulfide isomerase related protein ERp46. J. Mol. Biol., 425 (8), 1340-1362
Moniot, S., Schutkowski, M., & Steegborn, C. (2013) Crystal Structure Analysis of Human Sirt2 and its ADP-ribose Complex. J. Structural Biology, doi:pii: S1047-8477(13)00049-X. 10.1016/j.jsb.2013.02.012. [Epub ahead of print]
Rentzsch, A., Kahlert, V., Jahreis, G., Schlott, B., Schutkowski, M., Malesevic, M, & Fischer, G. (2013) The influence of cyclosporines on proteolytic reactions in cell extracts. Biol. Chem. doi:pii: /j/bchm.just-accepted/hsz-2013-0125/hsz-2013-0125.xml. 10.1515/hsz-2013-0125. [Epub ahead of print]
2012
Carducci, M, Perfetto, L., Briganti, L.,
Paoluzi, S., Costa, S., Zerweck, J., Schutkowski, M.,
Castagnoli, L, & Cesareni, G. (2012) The protein interaction network
mediated by human SH3 domains. Biotechnol Adv.,
30(1), 4-15
Fischer, F., Gertz, M., Suenkel, B., Lakshminarasimhan, M.,
Schutkowski, M., & Steegborn, C. (2012) Sirt5 Deacylation
Activities Show Differential Sensitivities to Nicotinamide Inhibition. PLOSone, 7, e45098, doi:
10.1371/journal.pone.0045098 Epub 2012 Sep 19.
2011
Thiele, A., Krentzlin, K., Erdmann, F., Rauh, D., Hause, G., Zerweck, J., Kilka, S.,
Pösel, S., Fischer, G., Schutkowski, M., & Weiwad, M. (2011)
Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl
cis/trans isomerase activity. J.
Mol. Biol., 411, 896-909
Wyszomirski, K.H., Curth, U., Alves,
J., Mackeldanz, P., Möncke-Buchner, E., Schutkowski, M.,
Krüger, D.H., & Reuter, M. (2011) Type III restriction endonuclease
EcoP15I is a heterotrimeric complex containing one Res subunit with
several DNA-binding regions and ATPase activity Nucl. Acids Res., Advance Access published
December 23
Thiele, A., Stangl, G., &
Schutkowski, M. (2011) Deciphering enzyme function using
peptide arrays. Molecular
Biotechnology, DOI 10.1007/s12033-011-9402-x
Kuhfahl, S., Hauburger, A., Thieme, T., Groppe, J., Ihling, C., Tomic, S.,
Schutkowski, M., Sinz, A., & Schwarz, E. (2011) Identification
of a core domain within the proregion of bone morphogenetic proteins
that interacts with the dimeric, mature domain. Biochem. Biophys. Res. Commun., 408, 300-305
Schnatbaum, K., Zerweck, J., Nehmer, J., Wenschuh, H.,
Schutkowski, M., & Reimer, U. (2011)
SpikeTides™—proteotypic peptides for large-scale MS-
based proteomics. Application
NotesNature Methods, March 2011 (This article was submitted by a
commercial organisation and has not been peer reviewed!)
Reimer, U., Reineke , U., &
Schutkowski, M. (2011) Peptide arrays for the analysis of
antibody epitope recognition patterns. Mini-Reviews in Organic Chemistry, 8, 137-146
Thiele, A., Pösel , S., Spinka , M.,
Zerweck , J., Reimer, U., Reineke , U., & Schutkowski, M.
(2011) Profiling of enzymatic activities using peptide arrays. Mini-Reviews in Organic
Chemistry, 8, 147-156
2010
Papadopoulos, C., Arato , K.,
Lilienthal, E., Zerweck , J., Schutkowski, M., Chatain , N.,
Müller-Newen , G., Becker, W., & De la Luna, S. (2010) Splice variants
of the dual-specificity tyrosine phosphorylation -regulated kinase 4
(DYRK4) differ in their subcellular localization and their catalytic
activity. J. Biol. Chem., 286, 5494-5505
Masch , A., Zerweck , J., &
Schutkowski, M. (2010) Antibody signatures defined by high-content
peptide microarray analysis . In Small Molecule Microarrays, Methods and
Protocols; Series: Methods in Molecular Biology, Vol. 669, edited by M. Uttamchandani and S.
Q. Yao), 161-172
Thiele, A., Weiwad , M., Zerweck , J.,
Fischer, G., & Schutkowski, M. (2010) High Density Peptide
Microarrays for Proteome-wide Fingerprinting of Kinase Activities in
Cell Lysates . In Small Molecule
Microarrays, Methods and Protocols; Series: Methods in Molecular
Biology, Vol. 669, edited
by M. Uttamchandani and S. Q. Yao, 173-181
Hewel , J.A., Liu, J., Onishi , K., Fong,
V., Chandran , S., Olsen, J.B., Pogoutse , O., Schutkowski, M.,
Wenschuh , H., Winkler, D.F., Eckler , L., Zandstra , P.W., & Emili , A.
(2010) Synthetic Peptide Arrays for Pathway-Level Protein Monitoring
by LC/MS. Mol Cell
Proteomics, 9, 2460-
2473
2009
Thiele, A., Zerweck, J., Weiwad, M.,
Fischer, G., & Schutkowski, M. (2009) High Density Peptide
Microarrays for Reliable Identification of Phosphorylation Sites and
Upstream Kinases. In Peptide
Microarrays, Methods and Protocols; Series: Methods in Molecular
Biology, Vol. 570, edited
by M. Cretich, and M. Chiari, Chapter 9, 203-219
Thiele, A., Zerweck, J., &
Schutkowski, M. (2009) Peptide Arrays for Enzyme Profiling. In
Peptide Microarrays,
Methods and Protocols; Series: Methods in Molecular Biology, Vol. 570, edited by M. Cretich,
and M. Chiari, Chapter 2, 19-65
Barak, N.N., Neumann, P., Sevvana,
M., Schutkowski, M., Naumann, K., Malesević, M.,
Reichardt, H., Fischer, G., Stubbs, M.T., Ferrari, D.M. (2009) Crystal
structure and functional analysis of the protein disulfide isomerase-
related protein ERp29. J. Mol.
Biol. 385, 1630-42.
Schutkowski, M. , Zerweck,
J., Masch, A., & Wenschuh, H. (2009) Antibody Signatures defined by
high-content peptide microarray analysis. Application Notes Nature Methods, March 2009
(This article was submitted by a commercial organisation and has not
been peer reviewed!)
Schutkowski, M. , Thiele, A.
& Koch, J. (2009) Peptide Arrays on Solid Supports: A Tool for the
Identification of Peptide Ligands. Peptides as Drugs. Discovery and Development.
Edited by Bernd Groner, Chapter 9, WILEY-VCH Verlag GmbH & Co.
KGaA, Weinheim (ISBN:978-3-527-32205-3), chapter 9, pp 187-
217
Gaseitsiwe, S., Valentine, D., Ahmed,
R., Mahdavifar, S., Magalhaes, I., Zerweck, J., Schutkowski, M.
, Gautherot, E., Montero, F., Ehrnst, A., Reilly, M., Maeurer, M.
(2009) MHC class II molecule - peptide complex analysis on a
microarray chip. Clin Vaccine
Immunol . , 16, 567-
573
Lorenz, P., Kreutzer, M., Zerweck, J.,
Schutkowski, M., and Thiesen, H .- J. (2009) Probing the
Epitope Signatures of IgG Antibodies in Human Serum from Patients
With Autoimmune Disease. Epitope Mapping Protocols, Second
Edition, Methods in Molecular Biology, Vol. 524 (Eds. Reineke, Ulrich & Schutkowski, Mike),
Chapter 18, 247-258.
Zerweck J., Masch, A. & Schutkowski,
M. (2009) Peptide Microarrays for Profiling of Modification State-
Specific Antibodies. Epitope Mapping Protocols, Second Edition,
Methods in Molecular Biology, Vol. 524 (Eds. Reineke, Ulrich & Schutkowski, Mike), Chapter
12, 169-180.
2008
Gaseitsiwe, S., Valentini, D.,
Mahdavifar, S., Magalhaes, I., Hoft, D.F., Zerweck, J., Schutkowski,
M., Andersson, J., Reilly, M., Maeurer, M.J. (2008) Pattern
Recognition in Pulmonary Tuberculosis Defined by High Content
Peptide Microarray Chip Analysis Representing 61 Proteins from M.
tuberculosis. PLoS ONE, 3, e3840.
Nahtman, T., Jernberg, A.,
Mahdavifar, S., Zerweck, J., Schutkowski, M., Mäurer, M., &
Reilly, M. (2007) Validation of peptide epitope microarray experiments
and extraction of quality data. J.
Immunological Methods, 328, 1-13.
2007
Tapia, V., Bongartz, J.,
Schutkowski, M., Bruni, N., Weiser, A., Ay, B., Volkmer, R., &
Or-Guil, M. (2007) Affinity profiling using the peptide microarray
technology: A case study. Analytical Biochemistry, 363, 108-118.
2006
Reineke, U., & Schutkowski,
M. (2006) Peptide
Arrays, Review article in BioMEMS and Biomedical
Nanotechnology, Volume II: Micro and Nano-Technologies for
Genomics and Proteomics, edited by M. Ozkan and M.J. Heller
(Springer Science+Business Media, LLC, New York, 2006) pp. 161-
282.
Wildemann, D., Erdmann, F.,
Hernandez Alvarez, B., Stoller G., Zhou, X.Z., Fanghänel, J.,
Schutkowski, M., 4, Lu K.P., & Fischer G. (2006)
2005
Mah, A.S., Elia, A.E., Devgan, G.,
Ptacek, J., Schutkowski, M., Snyder, M., Yaffe, M.B., &
Deshaies, R.J. (2005)
Zhang, Y., Erdmann, F., Baumgrass ,
R., Schutkowski, M., & Fischer G. (2005) Unexpected side
chain effects at residue 8 of cyclosporin a derivatives allow
photoswitching of immunosuppression. J. Biol. Chem., 280, 4842-4850.
Schutkowski, M., Reineke, U.,
& Reimer, U. (2005) Peptide arrays for kinase profiling. Chembiochem . , 6, 513-521
Yu , C., Malesevic , M., Jahreis , G.,
Schutkowski, M., Fischer, G., & Schiene-Fischer, C. (2005)
The architecture of protein-ligand binding sites revealed through
template-assisted intramolecular peptide-peptide interactions. Angew . Chem. Int. Ed Engl., 44, 1408-1412.
2004
Schutkowski, M. , Reimer,
U., Panse, S., Dong, L., Lizcano, J.M., Alessi, D.R., & Schneider-
Mergener, J. (2004)
Panse , S., Dong , L., Burian , A.,
Carus, R., Schutkowski, M., Reimer, U., & Schneider-
Mergener , J. (2004) Profiling of generic anti-phosphopeptide
antibodies and kinases with peptide microarrays using radioactive and
fluorescence-based assays. Mol.
Divers . , 8, 291-299.
Zhang, Y., Baumgrass , R.,
Schutkowski, M., & Fischer, G. (2004) Branches on the alpha-
C atom of cyclosporin A residue 3 result in direct calcineurin inhibition
and rapid cyclophilin 18 binding. Chembiochem ., 5, 1006-1009.
Rychlewski , L., Kschischo , M., Dong
, L., Schutkowski, M., & Reimer, U. (2004) Target specificity
analysis of the Abl kinase using peptide microarray data. J. Mol. Biol., 336, 307-311.
2003
Boudeau, J., Baas, A.F., Deak, M.,
Morrice, N.A., Kieloch, A., Schutkowski, M., Prescott, A.R.,
Clevers, H.C., & Alessi, D.R. (2003)
2002
Zhang, Y., Füssel , S., Reimer, U.,
Schutkowski, M., & Fischer, G. (2002) Substrate-based
design of reversible Pin1 inhibitors. Biochemistry, 41, 11868-77.
Lizcano, J.M., Deak, M., Morrice, N.,
Kieloch, A., Hastie, C.J., Dong, L., Schutkowski, M., Reimer,
U., & Alessi, D.R. (2002)
2000
Weiwad , M., Küllertz , G.,
Schutkowski, M., & Fischer G. (2000) Evidence that the
substrate backbone conformation is critical to phosphorylation by p42
MAP kinase. FEBS Lett ., 478, 39-42.
Frank, R., Jakob, M., Thunecke, F.,
Fischer, G., & Schutkowski, M. (2000) Thioxylation as One-
Atom-Substitution Generates a Photoswitchable Element within the
Peptide Backbone. Angew.
Chem. Int. Ed Engl., 39, 1120-1122.
1999
Wildemann, D., Drewello , M., Fischer,
G., & Schutkowski, M. (1999) Extremely Selective, Mg(
ClO4)2 Mediated Removal of Bpoc/Ddz-
Moieties Suitable for the Solid Phase Peptide Synthesis of Thioxo
Peptides. J. Chem. Soc., Chem.
Commun ., 1809-1810.
Schutkowski, M., Jacob, M.,
Reimer, U., Drewello , M, & Fischer, G. (1999) Cyclophilin Binding
Motifs and the HIV-1 p26 gag/Cyclophilin Interaction. Coll. Symposium Series, 1, 126-133.
Ke , H., Zhao, Y., Chen, Y.,
Schutkowski, M., & Fischer, G.(1999) Is the cis/trans isomerization of cyclophilin involved in
HIV-1 infectivity? Coll.
Symposium Series, 1,
187-193.
Bieri, O., Wirz, J., Hellrung, B,
Schutkowski, M., Drewello, M, & Kiefhaber, T. (1999)
1998
Schiene, C, Reimer, U.,
Schutkowski, M. & Fischer G. (1998) Mapping the
stereospecificity of peptidyl prolyl cis/trans isomerases. FEBS Lett ., 432, 202-206.
Reimer, U., Scherer, G., Drewello , M.,
Kruber , S., Schutkowski, M. & Fischer, G. (1998) Side-Chain
Effects on Peptidyl-Prolyl Cis/Trans Isomerization. J. Mol. Biol. 279, 449-460.
Scherer, G., Kramer. M., Reimer, U.,
Schutkowski, M. & Fischer, G. (1998) Barriers to Rotation of
Secondary Amide Peptide Bonds. J. Am. Chem. Soc . 120, 5568-5574.
Keller, M., Sager , C., Dumy , P.,
Schutkowski, M., Fischer, G., & Mutter, M. (1998) Enhancing
the Proline Effect: Pseudo-Prolines for Tailoring Cis/Trans Isomerization. J. Am. Chem. Soc. 120, 2714-2720.
Schutkowski, M ., Bernhardt,
A., Zhou, X.Z., Shen, M., Reimer, U., Rahfeld, J .- U., Lu, K.P., &
Fischer, G. (1998)
Brandsch , M., Thunecke, F., Küllertz ,
G., Schutkowski, M., Fischer, G., & Neubert, K. (1998)
Evidence for the absolute conformational specificity of the intestinal
H+/peptide symporter (PEPT1). J. Biol. Chem. 273, 3861-3864.
1997
Yaffe, M.B., Schutkowski, M.,
Shen, M., Stukenberg, P.T., Rahfeld, J .- U., Xu, J., Kuang, J.,
Kirschner, M.W., Fischer, G., Cantley, & Lu, K.P. (1997)
Reimer, U., Mokdad , N.,
Schutkowski, M., & Fischer, G. (1997) Intramolecular
assistance of cis/trans
isomerization of the His-Pro moiety. Biochemistry 36, 13802-13808.
Janowski, B., Wöllner , S.,
Schutkowski, M., & Fischer, G. (1997) A Protease-free Assay
for Peptidyl Prolyl cis/trans
isomerases Using Standard Peptide Substrates. Analytical Biochemistry 252, 299-307.
Pfeifer, T., Schierhorn, A.,
Friedemann, R., Jakob, M., Frank, R., Schutkowski, M., &
Fischer G. (1997) Specific Fragmentation of Thioxo Peptides
Facilitates the Assignment of the Thioxylated Amino Acid. J. Mass Spec. 32, 1064-1071.
Kern, D., Schutkowski, M., &
Drakenberg, T. (1997) Rotational Barriers of cis/trans Isomerization of
Proline Analogues and Their Catalysis by Cyclophilin. J. Am. Chem. Soc. 119 ,
8403-8408.
Bernhardt, A., Drewello, M., &
Schutkowski, M. (1997)
Reimer, U., Drewello , M., Jakob, M.,
Fischer, G., & Schutkowski, M. (1997) Conformational State of
a 25-mer Peptide from the Cyclophilin binding loop of the human
Immunodeficiency Virus Type 1 Capsid Protein. Biochemical J. 326, 181-185.
Schutkowski, M. , Jakob, M.,
Landgraf; G., Born, I., Neubert, K., & Fischer, G. (1997) Probing
Substrate Backbone Function in Prolyl Oligopeptidase Catalysis: Large
Positional Effects of Peptide Bond Monothioxylation. Eur. J. Biochemistry 245 , 381-385.
Zhao, Y., Chen, Y., Schutkowski,
M., Fischer, G., & Ke , H. (1997) Cyclophilin A complexed with a
fragment of HIV-1 gag polyprotein : insights into HIV-1 infectious
activity. Structure 5, 139-146.
1996
Kaspari , A., Schierhorn, A., &
Schutkowski, M. (1996) Solid-phase synthesis peptide-4-
nitroanilides. Int. J. Peptide
Protein Res. 48, 486-
494.
Frank, R., & Schutkowski, M.
(1996)
Schutkowski, M. , Drewello ,
M., Wöllner , S., Jakob, M., Reimer, U., Scherer, G., Schierhorn, A., &
Fischer, G. (1996)
Schutkowski, M., Wöllner , S.,
Drewello , M., & Fischer, G. (1996) The proline conformational switch -
novel data on chemistry and enzymology
Mayr , L. M., Odefey , C.,
Schutkowski, M., & Schmid , F.X. (1996)
Steffan, W., Schutkowski, M., &
Fischer, G. (1996) Synthesis of a chromogenic proline -containing
glycopeptide . J. Chem. Soc.,
Chem. Commun . , 313-314.
1995
Brandt, W., Lehmann, T, Thondorf, I.,
Born, I, Schutkowski, M., Rahfeld, J.-U., Neubert, K., & Barth,
A. (1995) A model of the active site of dipeptidyl peptidase IV predicted
by comparative molecular field analysis and molecular modelling
simulations. Int. J. Peptide
Protein Res . 46, 494-
507.
Schutkowski, M., Wöllner , S., &
Fischer, G. (1995) Inhibition of peptidyl-prolyl cis /trans
isomerase activity by substrate analog structures: thioxo tetrapeptide-
4-nitroanilides. Biochemistry
34, 13016-13026.
Schutkowski, M., Mrestani-
Klaus , C., & Neubert, K. (1995) Synthesis of dipeptide 4-nitroanilides
containing non-proteinogenic amino acids. Int. J. Peptide Protein Res . 45, 257-265.
1994
Meyer, S., Jabs , A., Schutkowski,
M., & Fischer, G. (1994) Separation of cis /trans
isomers of a prolyl peptide bond by capillary zone electrophoresis. Electrophoresis 15, 1151-1157.
Schutkowski, M., Neubert., K.,
& Fischer, G. (1994) Influence on proline -specific enzymes of a
substrate containing the thioxoaminoacyl-prolyl peptide bond. Eur . J. Biochem . 221, 455-461.
1991
Rahfeld, J.-U.,
Schutkowski, M., Faust, J., Neubert, K., Barth, A., & Heins, J.
(1991) Extended investigation of the substrate specificity of dipeptidyl
peptidase IV from pig kidney. Biol. Chem. Hoppe-Seyler 372, 313-318.