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2022

Kalbas, D., Meleshin, M., Liebscher, S., Zessin, M., Melesina, J., Schiene-Fischer, C., Bülbül, E.F., Bordusa, F., Sippl, W., Schutkowski, M. (2022) Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives. Biochemistry. doi: 10.1021/acs.biochem.2c00211.

Zessin, M., Meleshin, M., Praetorius, L., Sippl, W., Barinka, C., Schutkowski, M. (2022) Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms. ACS Chem Biol. 17(6):1364-1375. doi: 10.1021/acschembio.1c00863.

Cheshmazar, N., Hemmati, S., Hamzeh-Mivehroud, M., Sokouti, B., Zessin, M., Schutkowski, M., Sippl, W., Nozad Charoudeh, H., Dastmalchi, S. (2022) Development of New Inhibitors of HDAC1-3 Enzymes Aided by In Silico Design Strategies. J Chem Inf Model. 62(10):2387-2397. doi: 10.1021/acs.jcim.1c01557.

Bülbül, E.F., Melesina, J., Ibrahim, H.S., Abdelsalam, M., Vecchio, A., Robaa, D., Zessin, M., Schutkowski, M., Sippl, W. (2022) Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors. Molecules. 27(8):2526. doi: 10.3390/molecules27082526.

Kutil, Z., Meleshin, M., Baranova, P., Havlinova, B., Schutkowski, M., Barinka, C. (2022) Characterization of the class IIa histone deacetylases substrate specificity. FASEB J. 36(5):e22287. doi: 10.1096/fj.202101663R.

Ruhs, S., Griesler, B., Huebschmann, R., Stroedecke, K., Straetz, N., Ihling, C., Sinz, A., Masch, A., Schutkowski, M., Gekle, M., Grossmann, C. (2022) Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1. FASEB J. 36(1):e22059. doi: 10.1096/fj.202100977RR.

2021

Ibrahim, H.S., Abdelsalam, M., Zeyn, Y., Zessin, M., Mustafa, A.M., Fischer, M.A., Zeyen, P., Sun, P., Bülbül, E.F., Vecchio, A., Erdmann, F., Schmidt, M., Robaa, D., Barinka, C., Romier, C., Schutkowski, M., Krämer, O.H., Sippl, W. (2021) Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity. Int J Mol Sci. 23(1):369. doi: 10.3390/ijms23010369.

Zessin, M., Meleshin, M., Simic, Z., Kalbas, D., Arbach, M., Gebhardt, P., Melesina, J., Liebscher, S., Bordusa, F., Sippl, W., Barinka, C., Schutkowski, M. (2021) Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher. Bioorg Chem. 117:105425. doi: 10.1016/j.bioorg.2021.105425.

2020

Schnatbaum, K., Solis-Mezarino, V., Pokrovsky, D., Schäfer, F., Nagl, D., Hornberger, L., Zerweck, J., Knaute, T., Avramova-Nehmer, J., Schutkowski, M., Hornung, V., Wenschuh, H., Völker-Albert, M.C., Imhof, A., Reimer, U. (2020) New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics Based on a UV Active Tag. Proteomics. 20(10):e2000007. doi: 10.1002/pmic.202000007.

Ustinova, K., Novakova, Z., Saito, M., Meleshin, M.,, Mikesova, J., Kutil, Z., Baranova, P., Havlinova, B. Schutkowski, M., Matthias, P., Barinka, C., (2020) The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation. J Biol Chem. , Jan 17. pii: jbc.RA119.011243. doi: 10.1074/jbc.RA119.0112

2019

Kutil, Z., Mikešová, J., Zessin, M., Meleshin, M., , Nováková, Z., Alquicer, G., Kozikowski, A., Sippl, W., Bařinka, C., Schutkowski, M., (2019) Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors. ACS Omega.4(22), 19895-19904. doi: 10.1021/acsomega.9b02808.

Zessin, M., Kutil, Z., Meleshin, M., , Nováková, Z., Ghazy, E., Kalbas, D., Marek, M., Romier, C., Sippl, W., Bařinka, C., Schutkowski, M. (2019) One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry.58(48), 4777-4789. doi: 10.1021/acs.biochem.9b00786.

Kutil, Z., Skultetyova, L., Rauh, D., Meleshin, M., Snajdr, I., Novakova, Z., Mikesova, J., Pavlicek, J., Hadzima, M., Baranova, P., Havlinova, B., Majer, P., Schutkowski, M., Barinka, C., (2019) The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries. FASEB J. 33(3), 4035-4045. doi: 10.1096/fj.201801680R.

2018

Schumann, M., Malešević, M., Hinze, E., Mathea, S., Meleshin, M.,, Schutkowski, M., Haehnel, W., Schiene-Fischer, C.(2018) Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1. J Mol Biol. 307, 14-19. doi: 10.1016/j.jmb.2018.10.002.

Maksimov, P., Basso, W., Zerweck, J., Schutkowski, M. , Reimer, U., Maksimov, A., Conraths, F.J., Schares, G. (2018) Analysis of Toxoplasma gondii clonal type-specific antibody reactions in experimentally infected turkeys and chickens. Int J Parasitol. pii: S0020-7519(18), 30134-6. doi: 10.1016/j.ijpara.2018.04.004.

Kalbas, D., Liebscher, S., Nowak, T., Meleshin, M., Pannek, M., Popp, C., Alhalabi, Z., Bordusa, F., Sippl, W., Steegborn, C., Schutkowski, M. (2018) Potent and Selective Inhibitors of Human Sirtuin 5. J Med Chem. 61, 2460-2471. doi: 10.1021/acs.jmedchem.7b01648.

Kutil, Z., Novakova, Z.,Meleshin, M., Mikesova, J., Schutkowski, M., Barinka, C (2018) Histone Deacetylase 11 Is a Fatty-Acid Deacylase. ACS Chem Biol. 13, 685-693. doi: 10.1021/acschembio.7b00942.

2017

Blüher, D., Laha, D., Thieme, S., Hofer, A., Eschen-Lippold, L., Masch, A., Balcke, G., Pavlovic, I., Nagel, O., Schonsky, A., Hinkelmann, R., Wörner, J., Parvin, N., Greiner, R., Weber, S., Tissier, A., Schutkowski, M., Lee, J., Jessen, H., Schaaf, G. & Bonas, U. (2017) A 1-phytase type III effector interferes with plant hormone signaling. Nat Commun. 8,2159. doi: 10.1038/s41467-017-02195-8.

Pannek, M., Simic, Z., Fuszard, M., Meleshin, M., Rotili, D., Mai, A., Schutkowski, M. & Steegborn, C. (2017) Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun. 8, 1513. doi:10.1038/s41467-017-01701-2.

Ruhs, S., Strätz, N., Quarch, K., Masch, A., Schutkowski, M., Gekle, M. & Grossmann, C. (2017) Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2. Sci Rep. 7 15340. doi:10.1038/s41598-017-15418-1.

Schmohl, L., Bierlmeier, J., von Kügelgen, N., Kurz, L., Reis, P., Barthels, F., Mach, P., Schutkowski, M., Freund, C. & Schwarzer, D. (2017) Identification of sortase substrates by specificity profiling. Bioorg Med Chem. 25, 5002-5007. doi: 10.1016/j.bmc.2017.06.033.

Palma, A., Tinti, M., Paoluzi, S., Santonico, E., Brandt, B. W., Hooft van Huijsduijnen, R., Masch, A., Heringa, J., Schutkowski, M., Castagnoli, L. & Cesareni, G. (2017) Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases. J Biol Chem. 292, 4942-4952. doi: 10.1074/jbc.M116.757518.

You, W., Rotili, D., Li, T. M. , Kambach, C., Meleshin, M., Schutkowski, M., Chua, K. F., Mai, A. & Steegborn, C. (2017) Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew Chem Int Ed Engl.56, 1007-1011. doi: 10.1002/anie.201610082.

2016

Schuster, S., Roessler, C.,Meleshin, M., Zimmermann, P., Simic, Z., Kambach, C., Schiene-Fischer, C., Steegborn, C., Hottiger ,M. O. & Schutkowski, M. (2016) A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Sci Rep 4, 22643.doi: 10.1038/srep22643.

2015

Rohe, A., Platzer, C., Masch, A.,Greiner, S., Henze, C., Ihling, C., Erdmann, F., Schutkowski, M.,Sippl, W. & Schmidt, M. (2015) Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays. Bioorg Med Chem. 23, 4936-42. doi: 10.1016/j.bmc.2015.05.021.

Roessler, C., Tüting, C., Meleshin, M. , Steegborn, C., & Schutkowski, M. (2015) A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases. J Med Chem., 58, 7217-23. doi: 10.1021/acs.jmedchem.5b00293.

McCuaig, R.D., Dunn, J., Li. J., Masch, A., Knaute, T., Schutkowski, M., Zerweck, J. & Rao, S. (2015) PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation. Front Immunol., 6, 562. doi: 10.3389/fimmu.2015.00562.

Simic, Z., Weiwad, M., Schierhorn, A., Steegborn, C. & Schutkowski, M. (2015) The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters. Chembiochem., 16, 2337-47. doi: 10.1002/cbic.201500364.

Rumpf, T., Schiedel, M., Karaman, B. Roessler, C., North, B., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., & Jung, M. (2015) Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nature Struct. Biol., 6, 6263. doi: 10.1038/ncomms7263.

Polletta, L., Vernucci, E., Carnevale, I., Rotili, D., Nowak, T., Schutkowski, M., Pellegrini, L., Villanova, L., Sansone, L., Runci, A., Pucci, B., Fini, M., Mai, A., Russo, M.A., & Tafani, M. (2015) SIRT5 regulation of ammonia-induced autophagy/mitophagy. Feb 20:0. [Epub ahead of print]

2014

Maksimov, P., Zerweck, J., Dubey, J.P., Pantchev, N., Frey, C.F., Maksimov, A., Reimer, U., Schutkowski, M., Hosseininejad, M., Ziller, M., Conraths, F.J., Schares, G. (2013) Serotyping of Toxoplasma gondii in cats (Felis silvestris catus) reveals predominance of type II infections in Germany. PLOSone, 8(11), e80213

Schutkowski, M., Roessler, C., Fischer, F., & Steegborn, C. (2014) New assays and approaches for discovery and design of Sirtuin modulators. Expert Opinion On Drug Discovery, 9, 183-199

Perez-Bercoff, L., Valentini, D., Gaseitsiwe, S., Mahdavifar, S., Schutkowski, M., Poiret, T., Perez-Bercoff, A., Ljungman, P., & Maeurer, M.J. (2014) Whole CMV Proteome Pattern Recognition Analysis after HSCT Identifies Unique Epitope Targets Associated with the CMV Status. PLOSone, 9,, e89648

Roessler, C., Nowak, T., Pannek, M., Gertz, M., Nguyen, G.T.T., Scharfe, M., Born, I., Sippl, W., Steegborn, C., Schutkowski, M. (2014) Chemical probing of the human Sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors Angewandte Chemie DOI: 10.1002/anie.201402679

Schönberg, A, Bergner, E., Helm, S., Agne, B., Dünschede, B., Schünemann, D., Schutkowski, M., Baginsky, S. (2014) ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana. PLOSone, 9(10), e108344. doi: 10.1371/journal.pone.0108344. eCollection 2014

2013

Gertz, M., Fischer, F.,Nguyen, G.T.T., Lakshminarasimhan, M., Szczepankiewicz, B., Weyand, M., Schutkowski, M., & Steegborn, C. (2013) The Sirtuin inhibitor Ex-527 exploits their unique NAD+-dependent deacetylation mechanism. PNAS, 110(30), E2772-81

Rauh, D., Fischer, F., Gertz, M., Lakshminarasimhan, M., Bergbrede, T., Aladini, F., Becker, C.F.W., Zerweck, J., Schutkowski, M., & Steegborn, C. (2013) An acetylome peptide microarray reveals specificities and deacetylation substrates of all human Sirtuin isoforms. Nature Communications, 4, 2327

Tinti, M., Kiemer, L., Costa, S., Miller, M., Sacco, F., Olsen, J. V., Carducci, M., Paoluzi; S., Langone, F., Workman, C. T., Blom, N., Machida, K., Thomson, C. M., Schutkowski, M., Brunak, S., Mann, M., Mayer, B. J., Castagnoli, L., & Cesareni, G. (2013) The SH2 domain interaction landscape. Cell Reports, 3, 1-13

Lakshminarasimhan, M., Rauh, D. , Schutkowski, M., & Steegborn, C. (2013) Sirt1 activation by resveratrol is substrate sequence-selective. Aging, 5 (3), 1-4

Wolf, A., Rietscher, K., Glaß, M., Hüttelmaier, S., Schutkowski, M., Ihling, C., Sinz, A., Wingenfeld, A., Mun, A., & Hatzfeld, M. (2013) Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J. Cell Science, Advance Online Article, February 26, doi: 10.1242/ jcs.118992

Funkner, A., Parthier, C., Schutkowski, M., Zerweck, J., Lilie, H., Gyrych, N., Fischer, G., Stubbs, M.T., Ferrari, D.M. (2013) Peptide binding by catalytic domains of the protein disulfide isomerase related protein ERp46. J. Mol. Biol., 425 (8), 1340-1362

Moniot, S., Schutkowski, M., & Steegborn, C. (2013) Crystal Structure Analysis of Human Sirt2 and its ADP-ribose Complex. J. Structural Biology, doi:pii: S1047-8477(13)00049-X. 10.1016/j.jsb.2013.02.012. [Epub ahead of print]

Rentzsch, A., Kahlert, V., Jahreis, G., Schlott, B., Schutkowski, M., Malesevic, M, & Fischer, G. (2013) The influence of cyclosporines on proteolytic reactions in cell extracts. Biol. Chem. doi:pii: /j/bchm.just-accepted/hsz-2013-0125/hsz-2013-0125.xml. 10.1515/hsz-2013-0125. [Epub ahead of print]

2012

Carducci, M, Perfetto, L., Briganti, L., Paoluzi, S., Costa, S., Zerweck, J., Schutkowski, M., Castagnoli, L, & Cesareni, G. (2012) The protein interaction network mediated by human SH3 domains. Biotechnol Adv., 30(1), 4-15

Fischer, F., Gertz, M., Suenkel, B., Lakshminarasimhan, M., Schutkowski, M., & Steegborn, C. (2012) Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition. PLOSone, 7, e45098, doi: 10.1371/journal.pone.0045098 Epub 2012 Sep 19.

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2011

Thiele, A., Krentzlin, K., Erdmann, F., Rauh, D., Hause, G., Zerweck, J., Kilka, S., Pösel, S., Fischer, G., Schutkowski, M., & Weiwad, M. (2011) Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl cis/trans isomerase activity. J. Mol. Biol., 411, 896-909

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Wyszomirski, K.H., Curth, U., Alves, J., Mackeldanz, P., Möncke-Buchner, E., Schutkowski, M., Krüger, D.H., & Reuter, M. (2011) Type III restriction endonuclease EcoP15I is a heterotrimeric complex containing one Res subunit with several DNA-binding regions and ATPase activity Nucl. Acids Res., Advance Access published December 23

Thiele, A., Stangl, G., & Schutkowski, M. (2011) Deciphering enzyme function using peptide arrays. Molecular Biotechnology, DOI 10.1007/s12033-011-9402-x

Kuhfahl, S., Hauburger, A., Thieme, T., Groppe, J., Ihling, C., Tomic, S., Schutkowski, M., Sinz, A., & Schwarz, E. (2011) Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain. Biochem. Biophys. Res. Commun., 408, 300-305

Schnatbaum, K., Zerweck, J., Nehmer, J., Wenschuh, H., Schutkowski, M., & Reimer, U. (2011) SpikeTides™—proteotypic peptides for large-scale MS- based proteomics. Application NotesNature Methods, March 2011 (This article was submitted by a commercial organisation and has not been peer reviewed!)

Reimer, U., Reineke , U., & Schutkowski, M. (2011) Peptide arrays for the analysis of antibody epitope recognition patterns. Mini-Reviews in Organic Chemistry, 8, 137-146

Thiele, A., Pösel , S., Spinka , M., Zerweck , J., Reimer, U., Reineke , U., & Schutkowski, M. (2011) Profiling of enzymatic activities using peptide arrays. Mini-Reviews in Organic Chemistry, 8, 147-156

2010

Papadopoulos, C., Arato , K., Lilienthal, E., Zerweck , J., Schutkowski, M., Chatain , N., Müller-Newen , G., Becker, W., & De la Luna, S. (2010) Splice variants of the dual-specificity tyrosine phosphorylation -regulated kinase 4 (DYRK4) differ in their subcellular localization and their catalytic activity. J. Biol. Chem., 286, 5494-5505

Masch , A., Zerweck , J., & Schutkowski, M. (2010) Antibody signatures defined by high-content peptide microarray analysis . In Small Molecule Microarrays, Methods and Protocols; Series: Methods in Molecular Biology, Vol. 669, edited by M. Uttamchandani and S. Q. Yao), 161-172  

Thiele, A., Weiwad , M., Zerweck , J., Fischer, G., & Schutkowski, M. (2010) High Density Peptide Microarrays for Proteome-wide Fingerprinting of Kinase Activities in Cell Lysates . In Small Molecule Microarrays, Methods and Protocols; Series: Methods in Molecular Biology, Vol. 669, edited by M. Uttamchandani and S. Q. Yao, 173-181  

Hewel , J.A., Liu, J., Onishi , K., Fong, V., Chandran , S., Olsen, J.B., Pogoutse , O., Schutkowski, M., Wenschuh , H., Winkler, D.F., Eckler , L., Zandstra , P.W., & Emili , A. (2010) Synthetic Peptide Arrays for Pathway-Level Protein Monitoring by LC/MS. Mol Cell Proteomics, 9, 2460- 2473  

2009

Thiele, A., Zerweck, J., Weiwad, M., Fischer, G., & Schutkowski, M. (2009) High Density Peptide Microarrays for Reliable Identification of Phosphorylation Sites and Upstream Kinases. In Peptide Microarrays, Methods and Protocols; Series: Methods in Molecular Biology, Vol. 570, edited by M. Cretich, and M. Chiari, Chapter 9, 203-219  

Thiele, A., Zerweck, J., & Schutkowski, M. (2009) Peptide Arrays for Enzyme Profiling. In Peptide Microarrays, Methods and Protocols; Series: Methods in Molecular Biology, Vol. 570, edited by M. Cretich, and M. Chiari, Chapter 2, 19-65  

Barak, N.N., Neumann, P., Sevvana, M., Schutkowski, M., Naumann, K., Malesević, M., Reichardt, H., Fischer, G., Stubbs, M.T., Ferrari, D.M. (2009) Crystal structure and functional analysis of the protein disulfide isomerase- related protein ERp29. J. Mol. Biol. 385, 1630-42.  

Schutkowski, M. , Zerweck, J., Masch, A., & Wenschuh, H. (2009) Antibody Signatures defined by high-content peptide microarray analysis. Application Notes Nature Methods, March 2009 (This article was submitted by a commercial organisation and has not been peer reviewed!)  

Schutkowski, M. , Thiele, A. & Koch, J. (2009) Peptide Arrays on Solid Supports: A Tool for the Identification of Peptide Ligands. Peptides as Drugs. Discovery and Development. Edited by Bernd Groner, Chapter 9, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim (ISBN:978-3-527-32205-3), chapter 9, pp 187- 217  

Gaseitsiwe, S., Valentine, D., Ahmed, R., Mahdavifar, S., Magalhaes, I., Zerweck, J., Schutkowski, M. , Gautherot, E., Montero, F., Ehrnst, A., Reilly, M., Maeurer, M. (2009) MHC class II molecule - peptide complex analysis on a microarray chip. Clin Vaccine Immunol . , 16, 567- 573  

Lorenz, P., Kreutzer, M., Zerweck, J., Schutkowski, M., and Thiesen, H .- J. (2009) Probing the Epitope Signatures of IgG Antibodies in Human Serum from Patients With Autoimmune Disease. Epitope Mapping Protocols, Second Edition, Methods in Molecular Biology, Vol. 524 (Eds. Reineke, Ulrich & Schutkowski, Mike), Chapter 18, 247-258.  

Zerweck J., Masch, A. & Schutkowski, M. (2009) Peptide Microarrays for Profiling of Modification State- Specific Antibodies. Epitope Mapping Protocols, Second Edition, Methods in Molecular Biology, Vol. 524 (Eds. Reineke, Ulrich & Schutkowski, Mike), Chapter 12, 169-180.  

2008

Gaseitsiwe, S., Valentini, D., Mahdavifar, S., Magalhaes, I., Hoft, D.F., Zerweck, J., Schutkowski, M., Andersson, J., Reilly, M., Maeurer, M.J. (2008) Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. tuberculosis. PLoS ONE, 3, e3840.  

Nahtman, T., Jernberg, A., Mahdavifar, S., Zerweck, J., Schutkowski, M., Mäurer, M., & Reilly, M. (2007) Validation of peptide epitope microarray experiments and extraction of quality data. J. Immunological Methods, 328, 1-13.  

2007

Tapia, V., Bongartz, J., Schutkowski, M., Bruni, N., Weiser, A., Ay, B., Volkmer, R., & Or-Guil, M. (2007) Affinity profiling using the peptide microarray technology: A case study. Analytical Biochemistry, 363, 108-118.  

2006

Reineke, U., & Schutkowski, M. (2006) Peptide Arrays, Review article in BioMEMS and Biomedical Nanotechnology, Volume II: Micro and Nano-Technologies for Genomics and Proteomics, edited by M. Ozkan and M.J. Heller (Springer Science+Business Media, LLC, New York, 2006) pp. 161- 282.  

Wildemann, D., Erdmann, F., Hernandez Alvarez, B., Stoller G., Zhou, X.Z., Fanghänel, J., Schutkowski, M., 4, Lu K.P., & Fischer G. (2006) Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J. Med. Chem., 49, 2147-50.  

2005

Mah, A.S., Elia, A.E., Devgan, G., Ptacek, J., Schutkowski, M., Snyder, M., Yaffe, M.B., & Deshaies, R.J. (2005) Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem . , 6, 22-33.  

Zhang, Y., Erdmann, F., Baumgrass , R., Schutkowski, M., & Fischer G. (2005) Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression. J. Biol. Chem., 280, 4842-4850.  

Schutkowski, M., Reineke, U., & Reimer, U. (2005) Peptide arrays for kinase profiling. Chembiochem . , 6, 513-521  

Yu , C., Malesevic , M., Jahreis , G., Schutkowski, M., Fischer, G., & Schiene-Fischer, C. (2005) The architecture of protein-ligand binding sites revealed through template-assisted intramolecular peptide-peptide interactions. Angew . Chem. Int. Ed Engl., 44, 1408-1412.  

2004

Schutkowski, M. , Reimer, U., Panse, S., Dong, L., Lizcano, J.M., Alessi, D.R., & Schneider- Mergener, J. (2004) High-Content peptide microarrays for deciphering kinase specificity and biology. Angew . Chem., 116, 2725- 2728.  

Panse , S., Dong , L., Burian , A., Carus, R., Schutkowski, M., Reimer, U., & Schneider- Mergener , J. (2004)   Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays. Mol. Divers . , 8, 291-299.  

Zhang, Y., Baumgrass , R., Schutkowski, M., & Fischer, G. (2004) Branches on the alpha- C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding. Chembiochem ., 5, 1006-1009.  

Rychlewski , L., Kschischo , M., Dong , L., Schutkowski, M., & Reimer, U. (2004) Target specificity analysis of the Abl kinase using peptide microarray data. J. Mol. Biol., 336, 307-311.  

2003

Boudeau, J., Baas, A.F., Deak, M., Morrice, N.A., Kieloch, A., Schutkowski, M., Prescott, A.R., Clevers, H.C., & Alessi, D.R. (2003)   MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J., 22, 5102-5114.  

2002

Zhang, Y., Füssel , S., Reimer, U., Schutkowski, M., & Fischer, G. (2002)   Substrate-based design of reversible Pin1 inhibitors. Biochemistry, 41, 11868-77.  

Lizcano, J.M., Deak, M., Morrice, N., Kieloch, A., Hastie, C.J., Dong, L., Schutkowski, M., Reimer, U., & Alessi, D.R. (2002) Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. J. Biol. Chem., 277, 27839-27849.  

2000

Weiwad , M., Küllertz , G., Schutkowski, M., & Fischer G. (2000) Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase. FEBS Lett ., 478, 39-42.  

Frank, R., Jakob, M., Thunecke, F., Fischer, G., & Schutkowski, M. (2000) Thioxylation as One- Atom-Substitution Generates a Photoswitchable Element within the Peptide Backbone. Angew. Chem. Int. Ed Engl., 39, 1120-1122.  

1999

Wildemann, D., Drewello , M., Fischer, G., & Schutkowski, M. (1999) Extremely Selective, Mg( ClO4)2 Mediated Removal of Bpoc/Ddz- Moieties Suitable for the Solid Phase Peptide Synthesis of Thioxo Peptides. J. Chem. Soc., Chem. Commun ., 1809-1810.  

Schutkowski, M., Jacob, M., Reimer, U., Drewello , M, & Fischer, G. (1999) Cyclophilin Binding Motifs and the HIV-1 p26 gag/Cyclophilin Interaction. Coll. Symposium Series, 1, 126-133.  

Ke , H., Zhao, Y., Chen, Y., Schutkowski, M., & Fischer, G.(1999) Is the cis/trans isomerization of cyclophilin involved in HIV-1 infectivity? Coll. Symposium Series, 1, 187-193.  

Bieri, O., Wirz, J., Hellrung, B, Schutkowski, M., Drewello, M, & Kiefhaber, T. (1999)

The speed limit for protein folding measured by triplet- triplet energy transfer. Proc . Nat. Acad . Sci . U.S.A. , 96 , 9597-9601.

 

1998

Schiene, C, Reimer, U., Schutkowski, M. & Fischer G. (1998) Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases. FEBS Lett ., 432, 202-206.  

Reimer, U., Scherer, G., Drewello , M., Kruber , S., Schutkowski, M. & Fischer, G. (1998) Side-Chain Effects on Peptidyl-Prolyl Cis/Trans Isomerization. J. Mol. Biol. 279, 449-460.  

Scherer, G., Kramer. M., Reimer, U., Schutkowski, M. & Fischer, G. (1998) Barriers to Rotation of Secondary Amide Peptide Bonds. J. Am. Chem. Soc . 120, 5568-5574.  

Keller, M., Sager , C., Dumy , P., Schutkowski, M., Fischer, G., & Mutter, M. (1998) Enhancing the Proline Effect: Pseudo-Prolines for Tailoring Cis/Trans Isomerization. J. Am. Chem. Soc. 120, 2714-2720.  

Schutkowski, M ., Bernhardt, A., Zhou, X.Z., Shen, M., Reimer, U., Rahfeld, J .- U., Lu, K.P., & Fischer, G. (1998) Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition. Biochemistry 37, 5566-5575.  

Brandsch , M., Thunecke, F., Küllertz , G., Schutkowski, M., Fischer, G., & Neubert, K. (1998) Evidence for the absolute conformational specificity of the intestinal H+/peptide symporter (PEPT1). J. Biol. Chem. 273, 3861-3864.  

1997

Yaffe, M.B., Schutkowski, M., Shen, M., Stukenberg, P.T., Rahfeld, J .- U., Xu, J., Kuang, J., Kirschner, M.W., Fischer, G., Cantley, & Lu, K.P. (1997) Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Novel Mitotic Regulatory Mechanism. Science 278, 1957-1960.  

Reimer, U., Mokdad , N., Schutkowski, M., & Fischer, G. (1997) Intramolecular assistance of cis/trans isomerization of the His-Pro moiety. Biochemistry 36, 13802-13808.  

Janowski, B., Wöllner , S., Schutkowski, M., & Fischer, G. (1997) A Protease-free Assay for Peptidyl Prolyl cis/trans isomerases Using Standard Peptide Substrates. Analytical Biochemistry 252, 299-307.  

Pfeifer, T., Schierhorn, A., Friedemann, R., Jakob, M., Frank, R., Schutkowski, M., & Fischer G. (1997) Specific Fragmentation of Thioxo Peptides Facilitates the Assignment of the Thioxylated Amino Acid. J. Mass Spec. 32, 1064-1071.  

Kern, D., Schutkowski, M., & Drakenberg, T. (1997) Rotational Barriers of cis/trans Isomerization of Proline Analogues and Their Catalysis by Cyclophilin. J. Am. Chem. Soc. 119 , 8403-8408.  

Bernhardt, A., Drewello, M., & Schutkowski, M. (1997) The solid-phase synthesis of side chain phosphorylated peptide-4-nitroanilides. Int. J. Peptide Protein Res. 50 , 143-152.  

Reimer, U., Drewello , M., Jakob, M., Fischer, G., & Schutkowski, M. (1997) Conformational State of a 25-mer Peptide from the Cyclophilin binding loop of the human Immunodeficiency Virus Type 1 Capsid Protein. Biochemical J. 326, 181-185.  

Schutkowski, M. , Jakob, M., Landgraf; G., Born, I., Neubert, K., & Fischer, G. (1997) Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis: Large Positional Effects of Peptide Bond Monothioxylation. Eur. J. Biochemistry 245 , 381-385.  

Zhao, Y., Chen, Y., Schutkowski, M., Fischer, G., & Ke , H. (1997) Cyclophilin A complexed with a fragment of HIV-1 gag polyprotein : insights into HIV-1 infectious activity. Structure 5, 139-146.  

1996

Kaspari , A., Schierhorn, A., & Schutkowski, M. (1996) Solid-phase synthesis peptide-4- nitroanilides. Int. J. Peptide Protein Res. 48, 486- 494.  

Frank, R., & Schutkowski, M. (1996) Extremely mild reagent for Boc deprotection applicable to the synthesis of peptides with thioamide linkages. J. Chem. Soc., Chem. Commun ., 2509-2510.  

Schutkowski, M. , Drewello , M., Wöllner , S., Jakob, M., Reimer, U., Scherer, G., Schierhorn, A., & Fischer, G. (1996) Extended binding sites of cyclophilin as revealed by the interaction with HIV-1 Gag polyprotein derived oligopeptides . FEBS Letters 394, 289-294.  

Schutkowski, M., Wöllner , S., Drewello , M., & Fischer, G. (1996) The proline conformational switch - novel data on chemistry and enzymology Proceedings of 6th Akabori Conference, Protein Research Found. Minoh- shi , 166-171  

Mayr , L. M., Odefey , C., Schutkowski, M., & Schmid , F.X. (1996) Kinetic analysis of the unfolding and refolding of ribonuclease T1 by a stopped-flow double-mixing technique. Biochemistry 35, 5550-5561.  

Steffan, W., Schutkowski, M., & Fischer, G. (1996) Synthesis of a chromogenic proline -containing glycopeptide . J. Chem. Soc., Chem. Commun . , 313-314.  

1995

Brandt, W., Lehmann, T, Thondorf, I., Born, I, Schutkowski, M., Rahfeld, J.-U., Neubert, K., & Barth, A. (1995) A model of the active site of dipeptidyl peptidase IV predicted by comparative molecular field analysis and molecular modelling simulations. Int. J. Peptide Protein Res . 46, 494- 507.  

Schutkowski, M., Wöllner , S., & Fischer, G. (1995) Inhibition of peptidyl-prolyl cis /trans isomerase activity by substrate analog structures: thioxo tetrapeptide- 4-nitroanilides. Biochemistry 34, 13016-13026.  

Schutkowski, M., Mrestani- Klaus , C., & Neubert, K. (1995) Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids. Int. J. Peptide Protein Res . 45, 257-265.  

1994

Meyer, S., Jabs , A., Schutkowski, M., & Fischer, G. (1994) Separation of cis /trans isomers of a prolyl peptide bond by capillary zone electrophoresis. Electrophoresis 15, 1151-1157.  

Schutkowski, M., Neubert., K., & Fischer, G. (1994) Influence on proline -specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond. Eur . J. Biochem . 221, 455-461.  

1991

Rahfeld, J.-U., Schutkowski, M., Faust, J., Neubert, K., Barth, A., & Heins, J. (1991) Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney. Biol. Chem. Hoppe-Seyler 372, 313-318.  

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