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Schöpfel, M., Arnold, U. (2012) Significant stabilization of ribonuclease A by additive effects., FEBS J. 279(14), 2508-19

Sabrina Pfenning and Milton T. Stubbs (2012) Flexing and Stretching in Nonribosomal Peptide Synthetases, Chemistry & Biology 19, 167-169


Barbezier, N., Chartier, A., Bidet, Y., Buttstedt, A., Voisset, C., Galons, H., Blondel, M., Schwarz, E., Simonelig M., (2011): PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy involve the protein folding activity of rRNA and are reduced by 6-aminophenanthridine and guanabenz. EMBO Mol Med 3(1): 35-49

Buttstedt, A., Paoletti, F., Schwarz, E. (2011): Wachstumsfaktoren der
Cystin-Knoten-Familie und ihre Pro-Formen. BIOspektrum 2: 150-153

Schöpfel, M., Tziridis, A., Arnold, U., Stubbs, M.T. (2011) Towards a restriction proteinase: construction of a self-activating enzyme. Chembiochem. 12(10), 1523-7

Winter, J., Gleiter, S., Klappa, P. & Lilie, H. (2011) Protein disulfide isomerase (PDI) isomerizes non-native disulfide bonds in human proinsulin independent of its peptide binding activity. Prot. Science, 20(3), 588-596

Schroeder, T., Lilie, H., Lange, C. (2011) The myristoylation of guanylate cyclase-activating protein-2 causes an  increase in thermodynamic stability in the presence but not in the  absence of Ca(2+). Prot. Science, 20(7), 1155-1165

Theisgen, S., Thomas, L., Schroeder, T., Lange, C., Kovermann, M., Balbach, J., Huster, D. (2011) The presence of membranes or micelles induces structural changes of the myristoylated guanylate-cyclase activating protein-2. Eur. Biophys. J. 40(4), 565-576

Lilie, H., Bär, D., Kettner, K., Weininger, U., Balbach, J., Naumann, M., Müller, E-C., Otto, A., Gast, K., Golbik, R. & Kriegel., T. (2011) Yeast Hexokinase Isoenzyme ScHxk2 - Stability of a Two-Domain Protein with Discontinuous Domains. PEDS, 24, 79-87

Arouri, A., Kiessling, V., Tamm, L., Dathe, M., Blume, A. (2011)  Morphological changes induced by the action of antimicrobial peptides on supported lipid bilayers. J. Phys. Chem. B, 115, 158–167

Arouri, A., Kerth, A., Dathe, M., Blume, A. (2011) The binding of an amphipathic peptide to a lipid monolayer at the  air/water interface is modulated by the lipid headgroup structure.  Langmuir 27, 2881-2888.


Buttstedt, A., Winter, R., Sackewitz, M., Hause, G., Schmid, F.X., Schwarz  E. (2010): Influence of the stability of a fused protein and its distance to the
amyloidogenic segment on fibril formation. PLoS ONE 5(11): e15436

Dippe M., Ulbrich-Hofmann R. (2010). A spectrophotometric microtiterplate assay to determine the transphosphatidylation potential of phospholipase D. J. Am. Oil Chem. Soc. 87, 1005 - 1011

Reich, S., Golbik, R.P., Geissler, R., Lilie, H. & Behrens, S.E. (2010) Mechanism of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J. Biol. Chem., 285,13685-13693.

Falke, D., Schulz, K., Doberenz, C., Beyer, L., Lilie, H., Thiemer, B. & Sawers, R.G. (2010) Unexpected oligomeric structure of the FocA formate channel of Escherichia coli: a paradigm for the formate-nitrite-transporter family of integral membrane proteins. FEMS Microbiology Letters, 303, 69-75

Schulenburg, C., Weininger, U., Neumann, P., Meiselbach, H., Stubbs, M. T., Sticht, H., Balbach, J., Ulbrich-Hofmann, R., Arnold, U. (2010) Impact of the C-terminal Disulfide Bond on the Folding and Stability of Onconase.  ChemBioChem. 11,  978-986.


Hauburger, A., von Einem, S., Schwaerzer, G.K., Buttstedt, A., Zebisch, M., Schräml, M., Hortschansky, P., Knaus, P., Schwarz,  E. (2009): The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding. FEBS J 276: 6386-6398

Arouri, A., Dathe, M., Blume, A. (2009) Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes? Biochim. Biophys Acta 1788, 650-659.

Dimova, K., Kalkhof, S., Pottratz, I., Ihling, C., Rodriguez-Castaneda, F., Liepold, T., Griesinger, C., Brose, N., Sinz, A., Jahn, O. (2009) Structural Insights into the Calmodulin-Munc13 Interaction Obtained by Cross-Linking and Mass Spectrometry. Biochemistry, 48, 5908-5921.

Dippe, M., Ulbrich-Hofmann, R. (2009) Spectrophotometric determination of phosphatidic acid via iron(III) complexation for assaying phospholipase D activity. Anal Biochem. 392, 169-73.

Dippe, M., Ulbrich-Hofmann, R. (2009) Substrate specificity in phospholipid transformations by plant phospholipase D isoenzymes. Phytochemistry 70, 361-5.

Hofmann, H., Weininger, U., Löw, C., Golbik, R.P., Balbach, J. and Ulbrich-Hofmann, R. (2009) Fast amide protein exchange reveals close relation between native-state dynamics and unfolding kinetics. J. Am. Chem. Soc. 131, 140-146.

Löw, C., Homeyer, N. Weininger, U., Sticht, H., Balbach, J. (2009) Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between native and partially folded state. ACS Chem. Biol. 4, 53-63.

Müller, M. Q., de Koning, L. J., Schmidt, A., Ihling, C., Syha, Y., Rau, O., Mechtler, K., Schubert-Zsilavecz, M., and Sinz, A. (2009) An Innovative Method to Study Target Protein-Drug Interactions by Mass Spectrometry, J. Med. Chem. 52, 2875-2879.

Dreiocker, F., Müller, M.Q., Sinz, A., Schäfer, M. (2009), Collision-Induced Dissociative Chemical Cross-Linking Reagent for Protein Structure Characterization: Applied Edman Chemistry in the Gas Phase,  J. Mass Spectrom., 45 (2), 178-189

Neumann, P., Lieber, D., Meyer, S., Dautel, P., Kerth, A., Kraus, I., Garten, W. and Stubbs, M.T. (2009) Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals single-stranded RNA binding properties. Proc. Natl. Acad. Sci. USA 106, 3710-3715

Reuter, M., Schwieger, C., Meister, A., Karlsson, G., Blume, A. (2009) Poly-l-lysines and poly-l-arginines induce leakage of negatively charged phospholipid vesicles and translocate through the lipid bilayer upon electrostatic binding to the membrane. Biophys Chem. 144, 27-37.

Schulenburg, C., Löw, C., Weininger, U., Mrestani-Klaus, C., Hofmann, H., Balbach, J., Ulbrich-Hofmann, R., Arnold, U. (2009) The folding pathway of onconase is directed by a conserved intermediate. Biochemistry 48, 8449-8457.

Mrestani-Klaus, C., Kölbel, K., Ulbrich-Hofmann, R. (2009) Thermodynamic stability and native-state dynamics of porcine pancreatic phospholipase A2 studied by 1H NMR spectroscopic measurements. Adv. Exp. Med. Biol. 611, 67-68.


Berthelmann, F.
, Mehner, D., Richter, S., Lindenstrauß, U., Lünsdorf, H., Hause, G., Brüser, T. (2008) Recombinant expression of tatABC and tatAC results in the formation of interacting cytoplasmic TatA tubes in Escherichia coli,  J. Biol. Chem. 283, 25281-25289  

Dippe, M., Mrestani-Klaus, C., Schierhorn, A. and Ulbrich-Hofmann, R. (2008) Phospholipase D-catalyzed synthesis of new phospholipids with polar head groups. Chem. Phys. Lipids 152, 71-77.

Hofmann, H., Golbik, R.P., Wunderlich, M., Hübner, C.G. and Ulbrich-Hofmann, R. (2008) Coloumb forces control the density of the globule-state of barstar. J. Mol. Biol., 376, 597-605.

Kalkhof, S., Haehn, S., Ihling, C., Smyth, N. and Sinz, A., (2008) Determination of Disulfide Bond Patterns in Laminin ß1 Chain N-Terminal Domains by Nano-High Performance Liquid Chromatography/Matrix-Assisted Laser Desorption/Ionization Time-of-Flight/Time-of-Flight Mass Spectrometry, Rapid Commun. Mass Spectrom. 22, 1933-1940

Kalkhof, S. and Sinz, A. (2008) Chances and Pitfalls of Chemical Cross-Linking with Amine-Reactive N-Hydroxy Succinimide Esters, Anal. Bioanal. Chem. 392, 305-312

Kuppe, K., Kerth, A., Blume, A. and Ulbrich-Hofmann, R. (2008) Calcium-induced membrane microdomains trigger plant phospholipase D activity. ChemBioChem 9, 2853-2859.

Lodderstedt, G., Sachs, R., Faust, J., Bordusa, F., Kühn, U., Golbik, R., Kerth, A., Wahle, E., Balbach, J., Schwarz, E. (2008) Hofmeister salts and potential therapeutic compounds accelerate in vitro fibril formation of the N-terminal domain of PABPN1 containing a disease-causing alanine extension. Biochemistry. 47, 2181-2189.

Löw, C., Weininger, U., Neumann, P., Klepsch, M., Lilie, H., Stubbs, M. T., Balbach, J. (2008) "Structural insights into an equilibrium folding intermediate of an archael ankyrin repeat protein" PNAS 105, 3779-3784

Löw, C., Weininger, U., Lee, H., Schweimer, K., Neundorf, I., Beck-Sickinger, A., Pastor, R.W., Balbach, J. (2008). Structure and dynamics of Helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys. J. 95, 4315-4323.

Müller, M. Q., Roth, C., Sträter, N. and Sinz, A. (2008)
Expression and Purification of the Ligand-Binding Domain of Peroxisome Proliferator-Activated Receptor alpha, Protein Expr. Purif. 62, 185-189

Naarmann, I., Harnisch, C., Flach, N., Kremmer, E., Kühn, H., Ostareck, D.H. and Ostareck-Lederer, A. (2008) mRNA silencing in human erythroid cell maturation: hnRNP K controls the synthesis of its regulator c-Src.   J. Biol. Chem., 283, 18461-18472.    

Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K. (2008) Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.  Proc. Natl. Acad. Sci. USA 105, 17390-17395

Rohrberg, J., Sachs, R., Lodderstedt, G., Sackewitz, M., Balbach, J. and Schwarz, E. (2008). Monitoring fibril formation of the N-terminal domain of PABPN1 carrying an alanine repeat by tryptophan fluorescence and real-time NMR. FEBS Letters, 582, 1587-1592.

Ropers M.H., Meister A., Blume A., Ralet M.C. (2008) Pectin/Lipid assembly at the air-water interface - Effect of the pectin charge distribution. Biomacromolecules 9, 1306-1312

Sackewitz, M., Scheidt, H. A., Lodderstedt, G., Schwarz, E. and Huster, D.  (2008) Dynamical mapping of fibrils from a disease associated alanine expansion domain using proteolysis and solid-state NMR spectroscopy. J. Am. Chem. Soc. 130, 7172-7173.

Sackewitz, M., von Einem, S., Hause, G., Wunderlich, M., Schmid, F.-X. and Schwarz, E. (2008). A folded and functional protein domain in an amyloid-like fibril, Prot. Sci. 17, 1 - 11

Weidner, A., Neumann, P., Wille, G., Stubbs, M.T., Tittmann, K. (2008) Crystallization and preliminary X-ray diffraction analysis of full-length and proteolytically activated pyruvate oxidase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 179-181

Miersch O., Neumerkel J., Dippe M., Stenzel I., Wasternack C. (2008). Hydroxylated jasmonates are commonly occurring metabolites of jasmonic acid and contribute to a partial switch-off in jasmonate signaling. New Phytol. 177, 114 - 127


Adolph, D., Flach, N., Müller, K., Ostareck, D.H. and Ostareck-Lederer, A. (2007) Deciphering the crosstalk between hnRNP K and c-Src: The c-Src activation domain in hnRNP K is distinct from the site of interaction. Mol. Cell. Biol. 27, 1758-1770.

Arouri, A., Garidel, P., Kliche, W. and Blume, A. (2007) Hydrophobic interactions are the driving force for the binding of peptide mimotopes and Staphylococcal protein A to recombinant human IgG1. Eur. Biophys. J. 36, 647-660.

Behrendt, J., Lindenstrauß, U., and Brüser, T. (2007) TatC recruits TatB and prevents its multimerization in Escherichia coli. FEBS Letters 581, 4085-4090.

Bringezu, F., Majerowicz, M., Wen, Shaoying, S., Reuther, G., Tan, K.-T., Kuhlmann, J., Waldmann, H., Huster, D. (2007) Membrane binding of a lipidated N-Ras protein studied in lipid monolayers. Eur. Biophys. J. 36, 491-498.

Förster, G., Schwieger, C., Faber, F., Weber, T., Blume, A. (2007) Influence of Poly-L-lysine on the Structure of Dipalmitoylglycerophosphoglycerol/Water Dispersions Studied by X-Ray-Scattering. Eur. Biophys. J. 36, 425-435.

Lopes, D. H. J., Meister, A., Gohlke, A., Hauser, A., Blume, A., Winter, R. (2007) Mechanism of IAPP aggregation at lipid interfaces studied by infrared reflection absorption spectroscopy (IRRAS) Biophys. J. 93, 3132-3141.

Löw C., Weininger U., Zeeb M., Zhang W., Laue E.D., Schmid F.X., Balbach J. (2007), "Folding Mechanism of an Ankyrin Repeat Protein: Scaffold and Active Site Formation of Human CDK Inhibitor p19(INK4d)." J Mol. Biol., 373, 219-231.

Schulenburg, C., Ardelt, B., Ardelt, W., Arnold, U., Shogen, K., Ulbrich-Hofmann, R. and Darzynkiewicz, Z. (2007) The interdependence between catalytic activity, conformational stability, and cytotoxicity of onconase. Cancer Biol. Ther. 6, 1233-1239.

Schulenburg, C., Martinez-Senac, M.M., Löw, C., Golbik, R., Ulbrich-Hofmann, R., Arnold, U. (2007) "Identification of three phases in Onconase refolding". FEBS J. 274, 5826-33.

Stumpe, S., König, S. and Ulbrich-Hofmann, R. (2007) Insights into the structure of plant alpha-type phospholipase D. FEBS J. 274, 2630-2640.


Anders, A., Lilie, H., Franke, K., Kapp, L., Stelling, J., Gilles, E.D., Breunig, K.D. (2006). The galactose switch in Kluyveromyces lactis depends on nuclear competition between Gal4 and Gal1 for Gal80 binding.  J Biol Chem. 281, 29337-29348.

Arnold, U., Schulenburg, C., Schmidt, D. and Ulbrich-Hofmann, R. (2006) Contribution of the structural peculiarities of Onconase to its high stability and folding kinetics. Biochemistry 45, 3580-3587.

Dyck, M., Kerth, A., Blume, A., Lösche, M. (2006) Interaction of the neurotransmitter, neuropeptide Y (NPY), with phospholipid membranes: Infrared spectroscopic characterization at the air/water interface. J. Phys. Chem. B 110, 22152-22159.

Meister, A., Nicolini, C., Waldmann, H., Kuhlmann, J., Kerth, A., Winter, R., Blume, A. (2006) Insertion of lipidated ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS) Biophys. J. 91, 1388-1401.

Messias, A., Harnisch, C., Ostareck-Lederer, A., Sattler, M. and Ostareck, D.H. (2006) The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src mediated tyrosine phosphorylation. J. Mol. Biol. 361, 470-481.

Reuther, G., Tan, K.-T., Köhler, J., Nowak, C., Pampel, A., Arnold, K., Kuhlmann, J., Waldmann, H., and Huster, D. (2006) Backbone Structure of the Membrane Bound C-Terminus of Lipid-Modified Human N-Ras Protein. Angew. Chem. Int. Ed. 45, 1-6.

Reuther, G., Tan, K.-T., Vogel, A., Nowak, C., Arnold, K., Kuhlmann, J., Waldmann, H., and Huster, D. (2006) The Lipidated Membrane Anchor of Full Length N-Ras Protein Shows an Extensive Dynamics as Revealed by Solid-State NMR Spectroscopy. J. Am. Chem. Soc. 128, 13840-13846.

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., and  Tittmann, K. (2006), „The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography", Nat. Chem. Biol. 2,324-328.

Zeeb, M., Max, K.E., Weininger, U., Löw, C., Sticht, H., Balbach, J. (2006) "Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution.", Nucleic Acids Res. 34, 4561-4571.


Dyck, M., Kerth, A., Blume, A. and Loesche, M. (2005) Interaction of the Neurotransmitter, Neuropeptide Y, with Phospholipid Membranes: Infrared Spectroscopic Characterization at the Air/Water Interface. J. Phys. Chem. B 110, 22152-22159.

Maltseva, E., Brezesinski, G., Moehwald, H., Kerth, A., Blume, A. (2005) Adsorption of Amyloid b (1-40) peptide to differently charged phospholipid monolayers. ChemBioChem 6, 1817-1824.

Meister, A., Kerth, A., Blume, A. (2005) Adsorption kinetics of n-nonyl-beta-D-glucopyranoside at the air-water interface studied by infrared reflection absorption spectroscopy. J Phys Chem B. 109, 6239-46.

Tittmann, K., Wille, G., Golbik, R., Weidner, A., Ghisla, S. Hübner, G. (2005) Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair. Biochemistry 44, 13291-13303

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