Martin-Luther-Universität Halle-Wittenberg

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Enzymeffektoren für leukozytäre Peptidasen

Eur J Biochem 270 (2003) 2147-56
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites.
Lorey S, Stöckel-Maschek A, Faust J, Brandt W, Stiebitz B, Gorrell MD, Kähne T, Mrestani‑Klaus C, Wrenger S, Reinhold D, Ansorge S, Neubert K

Biol Chem 384 (2003) 657-65
Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets.
Bukowska A, Tadje J, Arndt M, Wolke C, Kähne T, Bartsch J, Faust J, Neubert K, Hashimoto Y, Lendeckel U

Biol Chem 383 (2002) 1133-8
The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S

J Biol Chem 277 (2002) 33170-7
Erratum in: J Biol Chem 277 (2002) 41294
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26).
Lorey S, Faust J, Mrestani-Klaus C, Kähne T, Ansorge S, Neubert K, Bühling F

J Immunology 166 (2001) 2041-8
Targeting Dipeptidyl Peptidase IV (CD26) Supresses Autoimmune Encephalomyelitis and Up-Regulator TGF-b1 Secretion in vivo.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S

Biochem Biophys Res Commun 274 (2000) 410-4
Dipeptidyl peptidase IV (DP IV/CD26) mRNA expression in PWM-stimulated T-cells is suppressed by specific DP IV inhibition, an effect mediated by TGF-beta(1).
Arndt M, Lendeckel U, Spiess A, Faust J, Neubert K, Reinhold D, Ansorge S

J Biol Chem 275 (2000) 22180-22186
Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the Thromboxane A2 receptor.
Wrenger S., Faust J, Mrestani-Klaus C, Fengler A, Stöckel-Maschek A, Lorey S, Kähne T, Brandt W, Neubert K, Ansorge S, Reinhold D

FEBS Letters 428 (1998) 100-4
Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes.
Reinhold D, Vetter RW, Mnich K, Bühling F, Lendeckel U, Born I, Faust J, Neubert K, Gollnick H, Ansorge S

Struktur-Wirkungs-Untersuchungen an Opioidpeptiden des ß-Casomorphintyps

J Pept Res 63 (2004) 29-35
Potent bradykinin antagonists containing N-benzylglycine or N-benzyl-l-alanine in position 8.
Dawidowska O, Prahl A, Kowalczyk W, Derdowska I, Lammek B, Wierzba TH, Juzwa W, Neubert K, Zabrocki J, Olejniczak B

Br J Pharmacol 140 (2003) 13-22
Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with m-opioid receptor-sensitizing properties.
Stirnweiss J, Hartrodt B, Greksch G, Stürzebecher U, Bohmer FD, Neubert K, Liebmann C

J Pept Res 57 (2001) 11-8
New analogues of bradykinin containing a conformationally restricted dipeptide fragment in their molecules.
Derdowska I, Prahl A, Neubert K, Hartrodt B, Kania A, Dobrowolski D, Melhem S, Trzeciak HI, Wierzba T, Lammek B

Studien zum Oligopeptidtransport

Eur J Pharm Sci 21 (2004) 61-7
Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1.
Knütter I, Hartrodt B, Theis S, Foltz M, Rastetter M, Daniel H, Neubert K, Brandsch M

J Med Chem 46 (2003) 5725-34
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.
Gebauer S, Knütter I, Hartrodt B, Brandsch M, Neubert K, Thondorf I

Am J Physiol Gastrointest Liver Physiol 283 (2002) G222-9
H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1.
Knütter I, Rubio-Aliaga I, Boll M, Hause G, Daniel H, Neubert K, Brandsch M

Mol Pharmacol 61 (2002) 214-21
Defining minimal structural features in substrates of the H+/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives.
Theis S, Hartrodt B, Kottra G, Neubert K, Daniel H

J Biol Chem 277 (2002) 7287-92
Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
Theis S, Knütter I, Hartrodt B, Brandsch M, Kottra G, Neubert K, Daniel H

Biochemistry 40 (2001) 4454-8
A novel inhibitor of the mammalian peptide transporter PEPT1.
Knütter I, Theis S, Hartrodt B, Born I, Brandsch M, Daniel H, Neubert K

Eur J Biochem 266 (1999) 502-8
Decisive structural determinants for the interaction of proline derivatives with the intestinal H+/peptide symporter.
Brandsch M, Knütter I, Thunecke F, Hartrodt B, Born I, Börner V, Hirche F, Fischer G, Neubert K

J Biol Chem 273 (1998) 3861-4
Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter PEPT1.
Brandsch M, Thunecke F, Küllertz G, Schutkowski M, Fischer G, Neubert K

Eur J Biochem 255 (1998) 698-702
Transport of amino acid aryl amides by the intestinal H+/peptide cotransport system PEPT1.
Börner V, Fei YJ, Hartrodt B, Ganapathy V, Leibach F, Neubert K, Brandsch M

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